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Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation

The Prunus mume seed is a by-product of the food industry, and we studied its potential as a food biomaterial, particularly for nutraceutical and inner beauty products. Alternative animal tests showed that an extract of P. mume ripened seed (PmRS) was not toxic on the skin. PmRS exhibited protective...

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Autores principales: Son, Hyeong-U, Choi, Hee-Jeong, Alam, Md Badrul, Jeong, Chae Gyeong, Lee, Hansong I, Kim, Solomon L., Zhao, Peijun, Kim, Tae-Ho, Lee, Sang-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189804/
https://www.ncbi.nlm.nih.gov/pubmed/34122721
http://dx.doi.org/10.1155/2021/5528795
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author Son, Hyeong-U
Choi, Hee-Jeong
Alam, Md Badrul
Jeong, Chae Gyeong
Lee, Hansong I
Kim, Solomon L.
Zhao, Peijun
Kim, Tae-Ho
Lee, Sang-Han
author_facet Son, Hyeong-U
Choi, Hee-Jeong
Alam, Md Badrul
Jeong, Chae Gyeong
Lee, Hansong I
Kim, Solomon L.
Zhao, Peijun
Kim, Tae-Ho
Lee, Sang-Han
author_sort Son, Hyeong-U
collection PubMed
description The Prunus mume seed is a by-product of the food industry, and we studied its potential as a food biomaterial, particularly for nutraceutical and inner beauty products. Alternative animal tests showed that an extract of P. mume ripened seed (PmRS) was not toxic on the skin. PmRS exhibited protective effects against ultraviolet- (UV-) induced skin aging in mice, confirmed by phenotypic indications, including increased collagen levels and decreased skin thickness. Compared with the UV-saline group, the UV-PmRS group showed increased levels of silent mating type information regulation 2 homolog 1 (SIRT1) and collagen and decreased matrix metalloproteinase- (MMP-) 1 expression. The protective effect of PmRS treatment against UVB-mediated cell viability was observed in vitro without any cytotoxicity, and PmRS prevented UVB-induced reactive oxygen species generation in HaCaT cells. PmRS downregulated MMP-1 and MMP-13 compared with the UVB-irradiated group. However, mRNA expressions of tissue inhibitor of metalloproteinase-1 and SIRT1 were upregulated by PmRS treatment. MMP-1 and SIRT1 treated with PmRS were decreased and increased, respectively, at the protein level. Moreover, PmRS treatment reduced c-Jun N-terminal kinase and p38 phosphorylation compared with the UVB-treated group. We postulate that P. mume seed could be a useful ingredient in nutraceuticals and inner beauty-purpose foods.
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spelling pubmed-81898042021-06-11 Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation Son, Hyeong-U Choi, Hee-Jeong Alam, Md Badrul Jeong, Chae Gyeong Lee, Hansong I Kim, Solomon L. Zhao, Peijun Kim, Tae-Ho Lee, Sang-Han Oxid Med Cell Longev Research Article The Prunus mume seed is a by-product of the food industry, and we studied its potential as a food biomaterial, particularly for nutraceutical and inner beauty products. Alternative animal tests showed that an extract of P. mume ripened seed (PmRS) was not toxic on the skin. PmRS exhibited protective effects against ultraviolet- (UV-) induced skin aging in mice, confirmed by phenotypic indications, including increased collagen levels and decreased skin thickness. Compared with the UV-saline group, the UV-PmRS group showed increased levels of silent mating type information regulation 2 homolog 1 (SIRT1) and collagen and decreased matrix metalloproteinase- (MMP-) 1 expression. The protective effect of PmRS treatment against UVB-mediated cell viability was observed in vitro without any cytotoxicity, and PmRS prevented UVB-induced reactive oxygen species generation in HaCaT cells. PmRS downregulated MMP-1 and MMP-13 compared with the UVB-irradiated group. However, mRNA expressions of tissue inhibitor of metalloproteinase-1 and SIRT1 were upregulated by PmRS treatment. MMP-1 and SIRT1 treated with PmRS were decreased and increased, respectively, at the protein level. Moreover, PmRS treatment reduced c-Jun N-terminal kinase and p38 phosphorylation compared with the UVB-treated group. We postulate that P. mume seed could be a useful ingredient in nutraceuticals and inner beauty-purpose foods. Hindawi 2021-06-01 /pmc/articles/PMC8189804/ /pubmed/34122721 http://dx.doi.org/10.1155/2021/5528795 Text en Copyright © 2021 Hyeong-U Son et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Son, Hyeong-U
Choi, Hee-Jeong
Alam, Md Badrul
Jeong, Chae Gyeong
Lee, Hansong I
Kim, Solomon L.
Zhao, Peijun
Kim, Tae-Ho
Lee, Sang-Han
Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation
title Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation
title_full Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation
title_fullStr Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation
title_full_unstemmed Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation
title_short Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation
title_sort prunus mume seed exhibits inhibitory effect on skin senescence via sirt1 and mmp-1 regulation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189804/
https://www.ncbi.nlm.nih.gov/pubmed/34122721
http://dx.doi.org/10.1155/2021/5528795
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