Capsule and Sprinkle Formulations of Lubiprostone Are Not Biologically Similar in Patients with Functional Constipation

INTRODUCTION: Lubiprostone capsules are approved for managing three different chronic constipation conditions. A “sprinkle” formulation may facilitate use in individuals with difficulty swallowing capsules. Our objective was to evaluate the bioequivalence, pharmacokinetics (PK), and bioavailability...

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Detalles Bibliográficos
Autores principales: Adams, Atoya, Barish, Charles, Chen, Angel, Dennis, Patrick, Krause, Richard, Lichtlen, Peter, Losch-Beridon, Taryn, Mareya, Shadreck, Schneider, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190023/
https://www.ncbi.nlm.nih.gov/pubmed/33834354
http://dx.doi.org/10.1007/s12325-021-01707-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190023/
https://www.ncbi.nlm.nih.gov/pubmed/33834354
http://dx.doi.org/10.1007/s12325-021-01707-9

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