Substitution of histidine 30 by asparagine in manganese superoxide dismutase alters biophysical properties and supports proliferation in a K562 leukemia cell line

We have generated a mutant of C. elegans manganese superoxide dismutase at histidine 30 by site-directed mutagenesis. The structure was solved at a resolution of 1.52 Å by X-ray crystallography (pdb: 6S0D). His30 was targeted, as it forms as a gateway residue at the top of the solvent access funnel...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonetta, Rosalin, Hunter, Gary J., Trinh, Chi H., Borowski, Tomasz, Fenech, Anthony G., Kulp, Maria, Tabares, Leandro C., Un, Sun, Hunter, Thérèse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190026/
https://www.ncbi.nlm.nih.gov/pubmed/34021366
http://dx.doi.org/10.1007/s00249-021-01544-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190026/
https://www.ncbi.nlm.nih.gov/pubmed/34021366
http://dx.doi.org/10.1007/s00249-021-01544-2

Ejemplares similares