Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice

In brown adipose tissue, thermogenesis is suppressed by thioesterase superfamily member 1 (Them1), a long chain fatty acyl-CoA thioesterase. Them1 is highly upregulated by cold ambient temperature, where it reduces fatty acid availability and limits thermogenesis. Here, we show that Them1 regulates...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yue, Imai, Norihiro, Nicholls, Hayley T., Roberts, Blaine R., Goyal, Samaksh, Krisko, Tibor I., Ang, Lay-Hong, Tillman, Matthew C., Roberts, Anne M., Baqai, Mahnoor, Ortlund, Eric A., Cohen, David E., Hagen, Susan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190112/
https://www.ncbi.nlm.nih.gov/pubmed/34108467
http://dx.doi.org/10.1038/s41467-021-23595-x

Ejemplares similares

Ejemplares similares