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Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition

Human PARP2/ARTD2 is an ADP-ribosyltransferase which, when activated by 5′-phosphorylated DNA ends, catalyses poly-ADP-ribosylation of itself, other proteins and DNA. In this study, a crystal structure of PARP2 in complex with an activating 5′-phosphorylated DNA shows that the WGR domain bridges the...

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Detalles Bibliográficos
Autores principales:	Obaji, Ezeogo, Maksimainen, Mirko M., Galera-Prat, Albert, Lehtiö, Lari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190142/ https://www.ncbi.nlm.nih.gov/pubmed/34108479 http://dx.doi.org/10.1038/s41467-021-23800-x

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