Cargando…

WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression

WSX1, a receptor subunit for IL-27, is widely expressed in immune cells and closely involved in immune response, but its function in nonimmune cells remains unknown. Here we report that WSX1 is highly expressed in human hepatocytes but downregulated in hepatocellular carcinoma (HCC) cells. Using NRA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Man, Xia, Xueqing, Hu, Jiemiao, Fowlkes, Natalie Wall, Li, Shulin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190270/ https://www.ncbi.nlm.nih.gov/pubmed/34108491 http://dx.doi.org/10.1038/s41467-021-23864-9

Ejemplares similares

WSX1 Expression in Tumors Induces Immune Tolerance via Suppression of Effector Immune Cells
por: Dibra, Denada, et al.
Publicado: (2011)

Immune checkpoint regulator PD-L1 expression on tumor cells by contacting CD11b positive bone marrow derived stromal cells
por: Noh, Hyangsoon, et al.
Publicado: (2015)

TCCR/WSX-1 is a novel angiogenic factor in age-related macular degeneration
por: Sung, Ho Jin, et al.
Publicado: (2012)

Generation of a monoclonal antibody against the glycosylphosphatidylinositol-linked protein Rae-1 using genetically engineered tumor cells
por: Hu, Jiemiao, et al.
Publicado: (2014)

Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells
por: Satelli, Arun, et al.
Publicado: (2016)

Induction of NKG2D ligand expression on tumor cells by CD8(+) T cell engagement-mediated activation of nuclear factor-kappa B and p300/CBP-associated factor
por: Hu, Jiemiao, et al.
Publicado: (2019)

Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor α (WSX-1)
por: Sugiyama, N, et al.
Publicado: (2008)

Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors
por: Hu, Jiemiao, et al.
Publicado: (2022)

WSX-1 Signalling Inhibits CD4(+) T Cell Migration to the Liver during Malaria Infection by Repressing Chemokine-Independent Pathways
por: Villegas-Mendez, Ana, et al.
Publicado: (2013)

Cigarette Smoke Induction of Interleukin-27/WSX-1 Regulates the Differentiation of Th1 and Th17 Cells in a Smoking Mouse Model of Emphysema
por: Qiu, Shi-Lin, et al.
Publicado: (2016)

BDH2 is downregulated in hepatocellular carcinoma and acts as a tumor suppressor regulating cell apoptosis and autophagy
por: Liang, Hao, et al.
Publicado: (2019)

CD8(+)T cell–specific induction of NKG2D receptor by doxorubicin plus interleukin-12 and its contribution to CD8(+)T cell accumulation in tumors
por: Hu, Jiemiao, et al.
Publicado: (2014)

A microfluidics-based method for isolation and visualization of cells based on receptor-ligand interactions
por: Dao, Long, et al.
Publicado: (2022)

FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells
por: Zhao, Qingnan, et al.
Publicado: (2023)

MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma
por: Wang, Jian, et al.
Publicado: (2012)

Regulation of tumor immune suppression and cancer cell survival by CXCL1/2 elevation in glioblastoma multiforme
por: Hu, Jiemiao, et al.
Publicado: (2021)

Kruppel-like factor 13 acts as a tumor suppressor in thyroid carcinoma by downregulating IFIT1
por: Liu, Yang, et al.
Publicado: (2023)

Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1
por: D’Alterio, Crescenzo, et al.
Publicado: (2019)

Insulin-like Growth Factor II Signaling in Neoplastic Proliferation Is Blocked by Transgenic Expression of the Metalloproteinase Inhibitor Timp-1
por: Martin, David C., et al.
Publicado: (1999)

PD-1/PD-L1 Blockade Therapy for Tumors with Downregulated MHC Class I Expression
por: Šmahel, Michal
Publicado: (2017)

Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes
por: Sun, Peng, et al.
Publicado: (2019)

Peripheral blood T lymphocytes are downregulated by the PD-1/PD-L1 axis in advanced gastric cancer
por: Zgodzinski, Witold, et al.
Publicado: (2018)

Myeloid-derived suppressor cells in non-neoplastic inflamed organs
por: Sendo, Sho, et al.
Publicado: (2018)

PD-L1 Downregulation and DNA Methylation Inhibition for Molecular Therapy against Cancer Stem Cells in Hepatocellular Carcinoma
por: Sukowati, Caecilia, et al.
Publicado: (2023)

Cathelicidin Antimicrobial Peptide Acts as a Tumor Suppressor in Hepatocellular Carcinoma
por: Huang, Lien-Hung, et al.
Publicado: (2023)

PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer
por: Qi, Guangying, et al.
Publicado: (2016)

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis
por: Wartewig, Tim, et al.
Publicado: (2017)

Clinical outcomes and influencing factors of PD-1/PD-L1 in hepatocellular carcinoma
por: Wang, Jiting, et al.
Publicado: (2021)

PD-1/PD-L1 checkpoint inhibitors in advanced hepatocellular carcinoma immunotherapy
por: Li, Qian, et al.
Publicado: (2022)

Androgen Activity Is Associated With PD-L1 Downregulation in Thyroid Cancer
por: O’Connell, Timmy J., et al.
Publicado: (2021)

TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer
por: Meyer, Rosana D., et al.
Publicado: (2017)

Knockdown of yes-associated protein inhibits proliferation and downregulates large tumor suppressor 1 expression in MHCC97H human hepatocellular carcinoma cells
por: WANG, CHENG, et al.
Publicado: (2015)

miRNA-411 acts as a potential tumor suppressor miRNA via the downregulation of specificity protein 1 in breast cancer
por: Guo, Liangfeng, et al.
Publicado: (2016)

Downregulation of the Tumor Suppressor TFF1 Is Required during Induction of Colon Cancer Progression by L1
por: Saha, Arka, et al.
Publicado: (2022)

ITM2A as a Tumor Suppressor and Its Correlation With PD-L1 in Breast Cancer
por: Zhang, Rui, et al.
Publicado: (2021)

The growth of non-solid neoplastic lung nodules is associated with low PD L1 expression, irrespective of sampling technique
por: Bortolotto, Chandra, et al.
Publicado: (2020)

In Vivo Antitumor Effects of MK615 Led by PD-L1 Downregulation
por: Yanaki, Masashi, et al.
Publicado: (2018)

Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade
por: Grauers Wiktorin, Hanna, et al.
Publicado: (2018)

Screening of cytochrome 4Z1 expression in human non-neoplastic, pre-neoplastic and neoplastic tissues
por: Al-saraireh, Yousef M, et al.
Publicado: (2020)

Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression
por: Lv, Tingting, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_enno2155sqt75f13tdo7rbmve8