Cargando…

Novel neutralizing human monoclonal antibodies against tetanus neurotoxin

Tetanus is a fatal disease caused by tetanus neurotoxin (TeNT). TeNT is composed of a light chain (Lc) and a heavy chain, the latter of which is classified into two domains, N-terminus Hn and C-terminus Hc. Several TeNT-neutralizing antibodies have been reported, but it remains unclear which TeNT do...

Descripción completa

Detalles Bibliográficos
Autores principales:	Minamitani, Takeharu, Kiyose, Karin, Otsubo, Ryota, Ito, Toshihiro, Akiba, Hiroki, Furuta, Rika A., Inoue, Tsuyoshi, Tsumoto, Kouhei, Satake, Masahiro, Yasui, Teruhito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190289/ https://www.ncbi.nlm.nih.gov/pubmed/34108521 http://dx.doi.org/10.1038/s41598-021-91597-2

Ejemplares similares

Optimization of anti-ADAMTS13 antibodies for the treatment of ADAMTS13-related bleeding disorder in patients receiving circulatory assist device support
por: Ito, Toshihiro, et al.
Publicado: (2021)

Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein
por: Otsubo, Ryota, et al.
Publicado: (2022)

Monoclonal antibody therapeutics for infectious diseases: Beyond normal human immunoglobulin
por: Otsubo, Ryota, et al.
Publicado: (2022)

Structural flexibility of the tetanus neurotoxin revealed by crystallographic and solution scattering analyses
por: Zhang, Chun-ming, et al.
Publicado: (2021)

A novel single-domain antibody multimer that potently neutralizes tetanus neurotoxin
por: de Smit, Hans, et al.
Publicado: (2021)

The Immunogenicity of the C Fragment of Tetanus Neurotoxin in Production of Tetanus Antitoxin
por: Yu, Rui, et al.
Publicado: (2018)

Tables of Toxicity of Botulinum and Tetanus Neurotoxins
por: Rossetto, Ornella, et al.
Publicado: (2019)

Neutralization of Botulinum Neurotoxin by a Human Monoclonal Antibody Specific for the Catalytic Light Chain
por: Adekar, Sharad P., et al.
Publicado: (2008)

Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update
por: Pirazzini, Marco, et al.
Publicado: (2022)

Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus
por: Fabris, Federico, et al.
Publicado: (2023)

Use of Monoclonal Antibodies in the Sensitive Detection and Neutralization of Botulinum Neurotoxin Serotype B
por: Cheng, Luisa W., et al.
Publicado: (2015)

Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B
por: Matsumura, Takuhiro, et al.
Publicado: (2020)

SV2 Mediates Entry of Tetanus Neurotoxin into Central Neurons
por: Yeh, Felix L., et al.
Publicado: (2010)

Novel Small Molecule Inhibitors That Prevent the Neuroparalysis of Tetanus Neurotoxin
por: Zanetti, Giulia, et al.
Publicado: (2021)

An oligoclonal combination of human monoclonal antibodies able to neutralize tetanus toxin in vivo
por: Aliprandini, Eduardo, et al.
Publicado: (2019)

Tetanus Neurotoxin Neutralizing Antibodies Screened from a Human Immune scFv Antibody Phage Display Library
por: Wang, Han, et al.
Publicado: (2016)

Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design
por: Akiba, Hiroki, et al.
Publicado: (2019)

Immunological Characterization and Neutralizing Ability of Monoclonal Antibodies Directed Against Botulinum Neurotoxin Type H
por: Fan, Yongfeng, et al.
Publicado: (2016)

Characterization of Neutralizing Human Anti-Tetanus Monoclonal Antibodies Produced by Stable Cell Lines
por: Manieri, Tania Maria, et al.
Publicado: (2022)

Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons
por: Hoogstraaten, Rein I., et al.
Publicado: (2020)

Characterization of Botulinum Neurotoxin Type A Neutralizing Monoclonal Antibodies and Influence of Their Half-Lives on Therapeutic Activity
por: Mazuet, Christelle, et al.
Publicado: (2010)

A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes
por: Garcia-Rodriguez, Consuelo, et al.
Publicado: (2018)

A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes
por: Fan, Yongfeng, et al.
Publicado: (2017)

A Four-Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotypes C and D
por: Garcia-Rodriguez, Consuelo, et al.
Publicado: (2021)

Ancient Clostridium DNA and variants of tetanus neurotoxins associated with human archaeological remains
por: Hodgins, Harold P., et al.
Publicado: (2023)

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes
por: Ledsgaard, Line, et al.
Publicado: (2023)

Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing
por: Akiba, Hiroki, et al.
Publicado: (2021)

Role of tetanus neurotoxin insensitive vesicle-associated membrane protein in membrane domains transport and homeostasis
por: Molino, Diana, et al.
Publicado: (2015)

The role of the single interchains disulfide bond in tetanus and botulinum neurotoxins and the development of antitetanus and antibotulism drugs
por: Rossetto, Ornella, et al.
Publicado: (2019)

Therapeutic effects of Tetanus neurotoxin in spinal cord injury: a case series on four dogs
por: Hesse, Stefan, et al.
Publicado: (2020)

High-Throughput IgG Epitope Mapping of Tetanus Neurotoxin: Implications for Immunotherapy and Vaccine Design
por: De-Simone, Salvatore G., et al.
Publicado: (2023)

Generation of biparatopic antibody through two-step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher
por: Akiba, Hiroki, et al.
Publicado: (2020)

Development and Characterization of Monoclonal Antibodies to Botulinum Neurotoxin Type E
por: Bever, Candace S., et al.
Publicado: (2019)

Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody
por: Fabris, Federico, et al.
Publicado: (2022)

Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B
por: Fan, Yongfeng, et al.
Publicado: (2015)

Neutralization of Botulinum Neurotoxin Type E by a Humanized Antibody
por: Derman, Yağmur, et al.
Publicado: (2016)

Intramuscular tetanus neurotoxin reverses muscle atrophy: a randomized controlled trial in dogs with spinal cord injury
por: Kutschenko, Anna, et al.
Publicado: (2021)

A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A
por: Lou, Jianlong, et al.
Publicado: (2018)

Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody
por: Akiba, Hiroki, et al.
Publicado: (2019)

Role of Tetanus Neurotoxin Insensitive Vesicle-Associated Membrane Protein (Ti-Vamp) in Vesicular Transport Mediating Neurite Outgrowth
por: Martinez-Arca, Sonia, et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_627vqmpdg1lrbkoghkh2bvt2ch