Random survival forests identify pathways with polymorphisms predictive of survival in KRAS mutant and KRAS wild-type metastatic colorectal cancer patients

KRAS status serves as a predictive biomarker of response to treatment in metastatic colorectal cancer (mCRC). We hypothesize that complex interactions between multiple pathways contribute to prognostic differences between KRAS wild-type and KRAS mutant patients with mCRC, and aim to identify polymor...

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Detalles Bibliográficos
Autores principales: Naseem, Madiha, Cao, Shu, Yang, Dongyun, Millstein, Joshua, Puccini, Alberto, Loupakis, Fotios, Stintzing, Sebastian, Cremolini, Chiara, Tokunaga, Ryuma, Battaglin, Francesca, Soni, Shivani, Berger, Martin D., Barzi, Afsaneh, Zhang, Wu, Falcone, Alfredo, Heinemann, Volker, Lenz, Heinz-Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190302/
https://www.ncbi.nlm.nih.gov/pubmed/34108518
http://dx.doi.org/10.1038/s41598-021-91330-z

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