Cargando…

Using Liposomes to Alleviate the Toxicity of Chelerythrine, a Natural PKC Inhibitor, in Treating Non-Small Cell Lung Cancer

AIM OF THE STUDY: CHE can inhibit the proliferation of lung cancer cells and induce apoptosis. However, despite having in vivo toxicity, CHE has not been thoroughly investigated in term of its in vivo antitumor effect. The present study evaluated the antitumor effect of CHE on non-small cell lung ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jiahui, Song, Yijie, Zhang, Ning, Li, Ning, Liu, Congying, Wang, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190388/ https://www.ncbi.nlm.nih.gov/pubmed/34123813 http://dx.doi.org/10.3389/fonc.2021.658543

Ejemplares similares

The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis
por: Ghashghaeinia, Mehrdad, et al.
Publicado: (2020)

Coronavirus disease 2019 (COVID-19), human erythrocytes and the PKC-alpha/-beta inhibitor chelerythrine –possible therapeutic implication
por: Ghashghaeinia, Mehrdad, et al.
Publicado: (2020)

Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency
por: Zheng, Weili, et al.
Publicado: (2015)

Natural Protein Kinase Inhibitors, Staurosporine, and Chelerythrine Suppress Wheat Blast Disease Caused by Magnaporthe oryzae Triticum
por: Chakraborty, Moutoshi, et al.
Publicado: (2022)

Chelerythrine Chloride: A Potential Rumen Microbial Urease Inhibitor Screened by Targeting UreG
por: Zhang, Xiaoyin, et al.
Publicado: (2021)

Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes
por: Bai, Li-Ping, et al.
Publicado: (2014)

Extraction of Chelerythrine and its Effects on Pathogenic Fungus Spore Germination
por: Wei, Qinghui, et al.
Publicado: (2017)

Rediscovery of Traditional Plant Medicine: An Underestimated Anticancer Drug of Chelerythrine
por: Chen, Nianzhi, et al.
Publicado: (2022)

The Atypical Protein Kinase C Small Molecule Inhibitor ζ-Stat, and Its Effects on Invasion Through Decreases in PKC-ζ Protein Expression
por: Smalley, Tracess, et al.
Publicado: (2020)

Antibacterial mechanism of chelerythrine isolated from root of Toddalia asiatica (Linn) Lam
por: He, Nan, et al.
Publicado: (2018)

Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells
por: Tang, Zheng-Hai, et al.
Publicado: (2017)

Synergistic Activity of Econazole-Nitrate and Chelerythrine against Clinical Isolates of Candida albicans
por: Chen, Zhibao, et al.
Publicado: (2014)

Protein kinase C inhibitor chelerythrine selectively inhibits proliferation of triple-negative breast cancer cells
por: Lin, Wanjun, et al.
Publicado: (2017)

In Vitro Antifungal Activity of Sanguinarine and Chelerythrine Derivatives against Phytopathogenic Fungi
por: Yang, Xin-Juan, et al.
Publicado: (2012)

Chelerythrine Chloride Downregulates β-Catenin and Inhibits Stem Cell Properties of Non-Small Cell Lung Carcinoma
por: Heng, Win Sen, et al.
Publicado: (2020)

Network pharmacology, molecular docking and experimental verification help unravel chelerythrine's potential mechanism in the treatment of gastric cancer
por: Kai, Kang, et al.
Publicado: (2023)

Therapeutic potential of chelerythrine as a multi-purpose adjuvant for the treatment of COVID-19
por: Valipour, Mehdi, et al.
Publicado: (2021)

Fluorescence, Absorption, Chromatography and Structural Transformation of Chelerythrine and Ethoxychelerythrine in Protic Solvents: A Comparative Study
por: Cao, Jinjin, et al.
Publicado: (2022)

Toxicities of Immunotherapy for Small Cell Lung Cancer
por: Fu, Yang, et al.
Publicado: (2021)

The toxicity associated with combining immune check point inhibitors with tyrosine kinase inhibitors in patients with non-small cell lung cancer
por: Kalra, Anjali, et al.
Publicado: (2023)

Clinical Outcomes Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Treated With Liposomal Irinotecan
por: Yu, Kenneth H., et al.
Publicado: (2021)

TDP-43 self-interaction is modulated by redox-active compounds Auranofin, Chelerythrine and Riluzole
por: Oberstadt, Moritz, et al.
Publicado: (2018)

Population Pharmacokinetics and Exposure–Safety Relationship of Paclitaxel Liposome in Patients With Non-small Cell Lung Cancer
por: Zhou, Haiyan, et al.
Publicado: (2021)

Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer
por: Yueh, Po-Fu, et al.
Publicado: (2021)

Chelerythrine induced cell death through ROS-dependent ER stress in human prostate cancer cells
por: Wu, Songjiang, et al.
Publicado: (2018)

Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines
por: CHEN, XIAO-MENG, et al.
Publicado: (2016)

Overcoming Resistance to Checkpoint Inhibitors: Natural Killer Cells in Non-Small Cell Lung Cancer
por: Gemelli, Maria, et al.
Publicado: (2022)

Serum cytokines predict efficacy and toxicity, but are not useful for disease monitoring in lung cancer treated with PD-(L)1 inhibitors
por: Schindler, Hannah, et al.
Publicado: (2022)

Obesity, Sarcopenia, and Outcomes in Non-Small Cell Lung Cancer Patients Treated With Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors
por: Khaddour, Karam, et al.
Publicado: (2020)

Patterns of Failure in Patients With Advanced Non-Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors
por: Chai, Rong, et al.
Publicado: (2021)

Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis
por: Zhou, Ping, et al.
Publicado: (2017)

Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ
por: Rimessi, Alessandro, et al.
Publicado: (2013)

Chelerythrine induces apoptosis via ROS‐mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma
por: He, Hongchao, et al.
Publicado: (2019)

Hyperprogressive disease in non-small cell lung cancer treated with immune checkpoint inhibitor therapy, fact or myth?
por: Britt, Alec S., et al.
Publicado: (2022)

Tumor Treating Fields Suppression of Ciliogenesis Enhances Temozolomide Toxicity
por: Shi, Ping, et al.
Publicado: (2022)

Effectiveness and safety of pembrolizumab for patients with advanced non-small cell lung cancer in real-world studies and randomized controlled trials: A systematic review and meta-analysis
por: Yang, Beibei, et al.
Publicado: (2023)

Concomitant Medication Effects on Immune Checkpoint Inhibitor Efficacy and Toxicity
por: Sieber, Brendan, et al.
Publicado: (2022)

Overcoming the cardiac toxicities of cancer therapy immune checkpoint inhibitors
por: Irabor, Omoruyi Credit, et al.
Publicado: (2022)

Inhibitor 9 Combined With Androgen Deprivation Therapy or Chemotherapy Delays the Malignant Behavior of Castration-Resistant Prostate Cancer Through K-Ras/PLCε/PKCε Signaling Pathway
por: Liu, Jiayu, et al.
Publicado: (2020)

PKCα Modulates Epithelial-to-Mesenchymal Transition and Invasiveness of Breast Cancer Cells Through ZEB1
por: Llorens, María Candelaria, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2vjj3jp7hhpumkngll10mlf0hb