Cargando…

Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure

Despite the ability of combination antiretroviral therapy (cART) to increase the life expectancy of patients infected with human immunodeficiency virus (HIV), viral reservoirs persist during life-long treatment. Notably, two cases of functional cure for HIV have been reported and are known as the “B...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Jingyi, Liu, Yanxi, Lai, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190402/
https://www.ncbi.nlm.nih.gov/pubmed/34122453
http://dx.doi.org/10.3389/fimmu.2021.688747
_version_ 1783705680302047232
author Ding, Jingyi
Liu, Yanxi
Lai, Yu
author_facet Ding, Jingyi
Liu, Yanxi
Lai, Yu
author_sort Ding, Jingyi
collection PubMed
description Despite the ability of combination antiretroviral therapy (cART) to increase the life expectancy of patients infected with human immunodeficiency virus (HIV), viral reservoirs persist during life-long treatment. Notably, two cases of functional cure for HIV have been reported and are known as the “Berlin Patient” and the “London Patient”. Both patients received allogeneic hematopoietic stem cell transplantation from donors with homozygous CCR5 delta32 mutation for an associated hematological malignancy. Therefore, there is growing interest in creating an HIV-resistant immune system through the use of gene-modified autologous hematopoietic stem cells with non-functional CCR5. Moreover, studies in CXCR4-targeted gene therapy for HIV have also shown great promise. Developing a cure for HIV infection remains a high priority. In this review, we discuss the increasing progress of coreceptor-based hematopoietic stem cell gene therapy, cART, milder conditioning regimens, and shock and kill strategies that have important implications for designing potential strategies aiming to achieve a functional cure for the majority of people with HIV.
format Online
Article
Text
id pubmed-8190402
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81904022021-06-11 Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure Ding, Jingyi Liu, Yanxi Lai, Yu Front Immunol Immunology Despite the ability of combination antiretroviral therapy (cART) to increase the life expectancy of patients infected with human immunodeficiency virus (HIV), viral reservoirs persist during life-long treatment. Notably, two cases of functional cure for HIV have been reported and are known as the “Berlin Patient” and the “London Patient”. Both patients received allogeneic hematopoietic stem cell transplantation from donors with homozygous CCR5 delta32 mutation for an associated hematological malignancy. Therefore, there is growing interest in creating an HIV-resistant immune system through the use of gene-modified autologous hematopoietic stem cells with non-functional CCR5. Moreover, studies in CXCR4-targeted gene therapy for HIV have also shown great promise. Developing a cure for HIV infection remains a high priority. In this review, we discuss the increasing progress of coreceptor-based hematopoietic stem cell gene therapy, cART, milder conditioning regimens, and shock and kill strategies that have important implications for designing potential strategies aiming to achieve a functional cure for the majority of people with HIV. Frontiers Media S.A. 2021-05-27 /pmc/articles/PMC8190402/ /pubmed/34122453 http://dx.doi.org/10.3389/fimmu.2021.688747 Text en Copyright © 2021 Ding, Liu and Lai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ding, Jingyi
Liu, Yanxi
Lai, Yu
Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure
title Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure
title_full Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure
title_fullStr Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure
title_full_unstemmed Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure
title_short Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure
title_sort knowledge from london and berlin: finding threads to a functional hiv cure
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190402/
https://www.ncbi.nlm.nih.gov/pubmed/34122453
http://dx.doi.org/10.3389/fimmu.2021.688747
work_keys_str_mv AT dingjingyi knowledgefromlondonandberlinfindingthreadstoafunctionalhivcure
AT liuyanxi knowledgefromlondonandberlinfindingthreadstoafunctionalhivcure
AT laiyu knowledgefromlondonandberlinfindingthreadstoafunctionalhivcure