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Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure
Despite the ability of combination antiretroviral therapy (cART) to increase the life expectancy of patients infected with human immunodeficiency virus (HIV), viral reservoirs persist during life-long treatment. Notably, two cases of functional cure for HIV have been reported and are known as the “B...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190402/ https://www.ncbi.nlm.nih.gov/pubmed/34122453 http://dx.doi.org/10.3389/fimmu.2021.688747 |
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author | Ding, Jingyi Liu, Yanxi Lai, Yu |
author_facet | Ding, Jingyi Liu, Yanxi Lai, Yu |
author_sort | Ding, Jingyi |
collection | PubMed |
description | Despite the ability of combination antiretroviral therapy (cART) to increase the life expectancy of patients infected with human immunodeficiency virus (HIV), viral reservoirs persist during life-long treatment. Notably, two cases of functional cure for HIV have been reported and are known as the “Berlin Patient” and the “London Patient”. Both patients received allogeneic hematopoietic stem cell transplantation from donors with homozygous CCR5 delta32 mutation for an associated hematological malignancy. Therefore, there is growing interest in creating an HIV-resistant immune system through the use of gene-modified autologous hematopoietic stem cells with non-functional CCR5. Moreover, studies in CXCR4-targeted gene therapy for HIV have also shown great promise. Developing a cure for HIV infection remains a high priority. In this review, we discuss the increasing progress of coreceptor-based hematopoietic stem cell gene therapy, cART, milder conditioning regimens, and shock and kill strategies that have important implications for designing potential strategies aiming to achieve a functional cure for the majority of people with HIV. |
format | Online Article Text |
id | pubmed-8190402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81904022021-06-11 Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure Ding, Jingyi Liu, Yanxi Lai, Yu Front Immunol Immunology Despite the ability of combination antiretroviral therapy (cART) to increase the life expectancy of patients infected with human immunodeficiency virus (HIV), viral reservoirs persist during life-long treatment. Notably, two cases of functional cure for HIV have been reported and are known as the “Berlin Patient” and the “London Patient”. Both patients received allogeneic hematopoietic stem cell transplantation from donors with homozygous CCR5 delta32 mutation for an associated hematological malignancy. Therefore, there is growing interest in creating an HIV-resistant immune system through the use of gene-modified autologous hematopoietic stem cells with non-functional CCR5. Moreover, studies in CXCR4-targeted gene therapy for HIV have also shown great promise. Developing a cure for HIV infection remains a high priority. In this review, we discuss the increasing progress of coreceptor-based hematopoietic stem cell gene therapy, cART, milder conditioning regimens, and shock and kill strategies that have important implications for designing potential strategies aiming to achieve a functional cure for the majority of people with HIV. Frontiers Media S.A. 2021-05-27 /pmc/articles/PMC8190402/ /pubmed/34122453 http://dx.doi.org/10.3389/fimmu.2021.688747 Text en Copyright © 2021 Ding, Liu and Lai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ding, Jingyi Liu, Yanxi Lai, Yu Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure |
title | Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure |
title_full | Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure |
title_fullStr | Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure |
title_full_unstemmed | Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure |
title_short | Knowledge From London and Berlin: Finding Threads to a Functional HIV Cure |
title_sort | knowledge from london and berlin: finding threads to a functional hiv cure |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190402/ https://www.ncbi.nlm.nih.gov/pubmed/34122453 http://dx.doi.org/10.3389/fimmu.2021.688747 |
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