Cargando…

Gain-of-function Tibetan PHD2(D4E;C127S) variant suppresses monocyte function: A lesson in inflammatory response to inspired hypoxia

BACKGROUND: We have previously described an evolutionarily selected Tibetan prolyl hydroxylase-2 (PHD2(D4E;C127S)) variant that degrades the hypoxia-inducible factor (HIFα) more efficiently and protects these highlanders from hypoxia-triggered elevation in haemoglobin concentration. High altitude is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhattacharya, Sulagna, Shrimali, Nishith M, Mohammad, Ghulam, Koul, Parvaiz A, Prchal, Josef T, Guchhait, Prasenjit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190441/ https://www.ncbi.nlm.nih.gov/pubmed/34102396 http://dx.doi.org/10.1016/j.ebiom.2021.103418

Ejemplares similares

α-Ketoglutarate Inhibits Thrombosis and Inflammation by Prolyl Hydroxylase-2 Mediated Inactivation of Phospho-Akt
por: Shrimali, Nishith M, et al.
Publicado: (2021)

Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases
por: Bhattacharya, Sulagna, et al.
Publicado: (2021)

Role of Platelet Cytokines in Dengue Virus Infection
por: Singh, Anamika, et al.
Publicado: (2020)

On either side of homeostasis: EPAS1 gain- and loss-of-function mutations
por: Prchal, Josef T., et al.
Publicado: (2023)

CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases
por: Zhang, Bin, et al.
Publicado: (2022)

Absence of Nonclassical Monocytes in Hemolytic Patients: Free Hb and NO-Mediated Mechanism
por: Singhal, Rashi, et al.
Publicado: (2019)

Dietary alpha‐ketoglutarate inhibits SARS CoV‐2 infection and rescues inflamed lungs to restore O(2) saturation by inhibiting pAkt
por: Agarwal, Sakshi, et al.
Publicado: (2022)

EPAS1 Gain-of-Function Mutation Contributes to High-Altitude Adaptation in Tibetan Horses
por: Liu, Xuexue, et al.
Publicado: (2019)

Role of Extracellular Hemoglobin in Thrombosis and Vascular Occlusion in Patients with Sickle Cell Anemia
por: Zhou, Zhou, et al.
Publicado: (2011)

Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents
por: Hura, Neha, et al.
Publicado: (2018)

Immunoprofiling of monocytes in STAT1 gain-of-function chronic mucocutaneous candidiasis
por: Bloomfield, Marketa, et al.
Publicado: (2022)

A Genome-Wide Search for Greek and Jewish Admixture in the Kashmiri Population
por: Downie, Jonathan M., et al.
Publicado: (2016)

PB2043: ERYTHROCYTOSIS IN PATIENTS WITH TIBETAN EGLN1C127S MUTATION: IS IT A POLYMORPHISM IN PATIENTS LIVING AT SEA LEVEL?
por: Biagetti, G., et al.
Publicado: (2022)

Pulmonary function testing during the COVID-19 pandemicin
por: Christopher, Devasahayam Jesudas, et al.
Publicado: (2021)

Inhibition of Hb Binding to GP1bα Abrogates Hb-Mediated Thrombus Formation on Immobilized VWF and Collagen under Physiological Shear Stress
por: Annarapu, Gowtham K., et al.
Publicado: (2016)

Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer
por: Lanikova, Lucie, et al.
Publicado: (2016)

Optimal Gestational Weight Gain for Tibetans Based on Prepregnancy Body Mass Index
por: Chen, Dajie, et al.
Publicado: (2020)

Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation
por: Zajíčková, Markéta, et al.
Publicado: (2022)

Volume 127 - Contents
Publicado: (2005)

Phd project
por: Marinho Valavicius, Priscilla
Publicado: (2020)

Surgery in limited-disease small-cell lung cancer
por: Koul, Parvaiz A.
Publicado: (2012)

Authors’ Reply
por: Koul, Parvaiz A.
Publicado: (2012)

Chronic obstructive pulmonary disease: Indian guidelines and the road ahead
por: Koul, Parvaiz A.
Publicado: (2013)

Ocular toxicity with ethambutol therapy: Timely recaution
por: Koul, Parvaiz A
Publicado: (2015)

Effective communication, the heart of the art of medicine
por: Koul, Parvaiz A
Publicado: (2017)

Metabolic syndrome and chronic obstructive pulmonary disease
por: Koul, Parvaiz A
Publicado: (2016)

Imaging of chest infections
por: Koul, Parvaiz A
Publicado: (2019)

Clinical practice guidelines for influenza and pneumococcal vaccination: The Indian perspective
por: Koul, Parvaiz A
Publicado: (2020)

Zoonotic helminthiasis: A challenge unabated
por: Koul, Parvaiz A
Publicado: (2023)

Disclosing use of Artificial Intelligence: Promoting transparency in publishing
por: Koul, Parvaiz A.
Publicado: (2023)

Research matters: How a brother with Down syndrome inspired a PhD in tuberculosis and an ardor for science communication
por: Wright, Meredith
Publicado: (2018)

Molecular Cloning and Functional Characterization of Tibetan Porcine STING
por: Huang, Zhiqing, et al.
Publicado: (2012)

Evolutionary history of Tibetans inferred from whole-genome sequencing
por: Hu, Hao, et al.
Publicado: (2017)

HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics
por: Chan, Xin Yi, et al.
Publicado: (2021)

127th SPSC Meeting
Publicado: (2017)

127th LHCC Meeting
Publicado: (2016)

India's fight against tuberculosis: How can chest physicians help?
por: Pai, Madhukar, et al.
Publicado: (2017)

PHD finger proteins function in plant development and abiotic stress responses: an overview
por: Quan, Wenli, et al.
Publicado: (2023)

Overexpression of the HIF Hydroxylases PHD1, PHD2, PHD3 and FIH Are Individually and Collectively Unfavorable Prognosticators for NSCLC Survival
por: Andersen, Sigve, et al.
Publicado: (2011)

PhD Project
por: Marinho Valavicius, Priscilla
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_501uub5chci7u1enqev3rn2b3d