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Activated microglia mitigate Aβ-associated tau seeding and spreading

In Alzheimer’s disease (AD) models, AD risk variants in the microglial-expressed TREM2 gene decrease Aβ plaque–associated microgliosis and increase neuritic dystrophy as well as plaque-associated seeding and spreading of tau aggregates. Whether this Aβ-enhanced tau seeding/spreading is due to loss o...

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Detalles Bibliográficos
Autores principales:	Gratuze, Maud, Chen, Yun, Parhizkar, Samira, Jain, Nimansha, Strickland, Michael R., Serrano, Javier Remolina, Colonna, Marco, Ulrich, Jason D., Holtzman, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190588/ https://www.ncbi.nlm.nih.gov/pubmed/34100905 http://dx.doi.org/10.1084/jem.20210542

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