Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations

Amyotrophic lateral sclerosis (ALS) is an adult-onset incurable motor neuron (MN) disease. The reasons for selective MN vulnerability in ALS are unknown. Axonal pathology is among the earliest signs of ALS. We searched for novel modulatory genes in human MN axon shortening affected by TARDBP mutatio...

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Detalles Bibliográficos
Autores principales: Mitsuzawa, Shio, Suzuki, Naoki, Akiyama, Tetsuya, Ishikawa, Mitsuru, Sone, Takefumi, Kawada, Jiro, Funayama, Ryo, Shirota, Matsuyuki, Mitsuhashi, Hiroaki, Morimoto, Satoru, Ikeda, Kensuke, Shijo, Tomomi, Ohno, Akiyuki, Nakamura, Naoko, Ono, Hiroya, Ono, Risako, Osana, Shion, Nakagawa, Tadashi, Nishiyama, Ayumi, Izumi, Rumiko, Kaneda, Shohei, Ikeuchi, Yoshiho, Nakayama, Keiko, Fujii, Teruo, Warita, Hitoshi, Okano, Hideyuki, Aoki, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190591/
https://www.ncbi.nlm.nih.gov/pubmed/34048688
http://dx.doi.org/10.1016/j.stemcr.2021.04.021

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