Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer

Induced pluripotent stem cells (iPSCs) and cancer cells share cellular similarities and transcriptomic profiles. Here, we show that an iPSC-based cancer vaccine, comprised of autologous iPSCs and CpG, stimulated cytotoxic antitumor CD8(+) T cell effector and memory responses, induced cancer-specific...

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Detalles Bibliográficos
Autores principales: Ouyang, Xiaoming, Liu, Yu, Zhou, Yang, Guo, Jing, Wei, Tzu-Tang, Liu, Chun, Lee, Bomi, Chen, Binbin, Zhang, Angela, Casey, Kerriann M., Wang, Lin, Kooreman, Nigel G., Habtezion, Aida, Engleman, Edgar G., Wu, Joseph C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190592/
https://www.ncbi.nlm.nih.gov/pubmed/33961792
http://dx.doi.org/10.1016/j.stemcr.2021.04.004

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