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Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism
PARK2 (parkin) mutations cause early-onset Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that participates in several cellular functions, including mitochondrial homeostasis. However, the specific metabolomic changes caused by parkin depletion remain unknown. Here, we used isogenic...
Autores principales: | Okarmus, Justyna, Havelund, Jesper F., Ryding, Matias, Schmidt, Sissel I., Bogetofte, Helle, Heon-Roberts, Rachel, Wade-Martins, Richard, Cowley, Sally A., Ryan, Brent J., Færgeman, Nils J., Hyttel, Poul, Meyer, Morten |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190670/ https://www.ncbi.nlm.nih.gov/pubmed/34048689 http://dx.doi.org/10.1016/j.stemcr.2021.04.022 |
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