Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors

Epigenetic alterations, particularly RNA methylation, play a crucial role in many types of disease development and progression. Among them, N6-methyladenosine (m6A) is the most common epigenetic RNA modification, and its important roles are not only related to the occurrence, progression, and aggres...

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Autores principales: Liu, Shuai, Lao, Yongfeng, Wang, Yanan, Li, Rongxin, Fang, Xuefeng, Wang, Yunchang, Gao, Xiaolong, Dong, Zhilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190709/
https://www.ncbi.nlm.nih.gov/pubmed/34124065
http://dx.doi.org/10.3389/fcell.2021.676364
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author Liu, Shuai
Lao, Yongfeng
Wang, Yanan
Li, Rongxin
Fang, Xuefeng
Wang, Yunchang
Gao, Xiaolong
Dong, Zhilong
author_facet Liu, Shuai
Lao, Yongfeng
Wang, Yanan
Li, Rongxin
Fang, Xuefeng
Wang, Yunchang
Gao, Xiaolong
Dong, Zhilong
author_sort Liu, Shuai
collection PubMed
description Epigenetic alterations, particularly RNA methylation, play a crucial role in many types of disease development and progression. Among them, N6-methyladenosine (m6A) is the most common epigenetic RNA modification, and its important roles are not only related to the occurrence, progression, and aggressiveness of tumors but also affect the progression of many non-tumor diseases. The biological effects of RNA m6A modification are dynamically and reversibly regulated by methyltransferases (writers), demethylases (erasers), and m6A binding proteins (readers). This review summarized the current finding of the RNA m6A modification regulators in male infertility and genital system tumors and discussed the role and potential clinical application of the RNA m6A modification in spermatogenesis and male genital system tumors.
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spelling pubmed-81907092021-06-11 Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors Liu, Shuai Lao, Yongfeng Wang, Yanan Li, Rongxin Fang, Xuefeng Wang, Yunchang Gao, Xiaolong Dong, Zhilong Front Cell Dev Biol Cell and Developmental Biology Epigenetic alterations, particularly RNA methylation, play a crucial role in many types of disease development and progression. Among them, N6-methyladenosine (m6A) is the most common epigenetic RNA modification, and its important roles are not only related to the occurrence, progression, and aggressiveness of tumors but also affect the progression of many non-tumor diseases. The biological effects of RNA m6A modification are dynamically and reversibly regulated by methyltransferases (writers), demethylases (erasers), and m6A binding proteins (readers). This review summarized the current finding of the RNA m6A modification regulators in male infertility and genital system tumors and discussed the role and potential clinical application of the RNA m6A modification in spermatogenesis and male genital system tumors. Frontiers Media S.A. 2021-05-19 /pmc/articles/PMC8190709/ /pubmed/34124065 http://dx.doi.org/10.3389/fcell.2021.676364 Text en Copyright © 2021 Liu, Lao, Wang, Li, Fang, Wang, Gao and Dong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Liu, Shuai
Lao, Yongfeng
Wang, Yanan
Li, Rongxin
Fang, Xuefeng
Wang, Yunchang
Gao, Xiaolong
Dong, Zhilong
Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors
title Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors
title_full Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors
title_fullStr Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors
title_full_unstemmed Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors
title_short Role of RNA N6-Methyladenosine Modification in Male Infertility and Genital System Tumors
title_sort role of rna n6-methyladenosine modification in male infertility and genital system tumors
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190709/
https://www.ncbi.nlm.nih.gov/pubmed/34124065
http://dx.doi.org/10.3389/fcell.2021.676364
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