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Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives
BACKGROUND: Interleukin-15 (IL-15) is a critical cytokine for the development, proliferation, and function of natural killer (NK) cells, NKT cells, and CD8(+) memory T cells and has become one of the most promising protein molecules for the treatment of cancer and viral diseases. However, there are...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190845/ https://www.ncbi.nlm.nih.gov/pubmed/34107983 http://dx.doi.org/10.1186/s12934-021-01605-3 |