SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ

Pathological lipid accumulation is often associated with enhanced uptake of free fatty acids via specific transporters in cardiomyocytes. Here, we identify SIRT6 as a critical transcriptional regulator of fatty acid transporters in cardiomyocytes. We find that SIRT6 deficiency enhances the expressio...

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Detalles Bibliográficos
Autores principales: Khan, Danish, Ara, Tarannum, Ravi, Venkatraman, Rajagopal, Raksha, Tandon, Himani, Parvathy, Jayadevan, Gonzalez, Edward A., Asirvatham-Jeyaraj, Ninitha, Krishna, Swati, Mishra, Sneha, Raghu, Sukanya, Bhati, Arvind Singh, Tamta, Ankit Kumar, Dasgupta, Subhajit, Kolthur-Seetharam, Ullas, Etchegaray, Jean-Pierre, Mostoslavsky, Raul, Rao, Prasanna Simha Mohan, Srinivasan, Narayanaswamy, Sundaresan, Nagalingam Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190874/
https://www.ncbi.nlm.nih.gov/pubmed/34077730
http://dx.doi.org/10.1016/j.celrep.2021.109190

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