Synthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction

[Image: see text] A concise and efficient cross-coupling synthetic strategy has been developed to construct 2-aryl-4H-thiochromen-4-one derivatives from 2-sulfinyl-thiochromones and arylboronic acids. This reaction proceeds via a catalyst system of Lewis acid and palladium(II) combined with XPhos as...

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Autores principales: Li, Peng, Li, Shengnan, Li, Gang, Huang, Haihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190924/
https://www.ncbi.nlm.nih.gov/pubmed/34124488
http://dx.doi.org/10.1021/acsomega.1c01778
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author Li, Peng
Li, Shengnan
Li, Gang
Huang, Haihong
author_facet Li, Peng
Li, Shengnan
Li, Gang
Huang, Haihong
author_sort Li, Peng
collection PubMed
description [Image: see text] A concise and efficient cross-coupling synthetic strategy has been developed to construct 2-aryl-4H-thiochromen-4-one derivatives from 2-sulfinyl-thiochromones and arylboronic acids. This reaction proceeds via a catalyst system of Lewis acid and palladium(II) combined with XPhos as an optimal ligand in moderate to good yields. Besides, this flexible methodology provides a wide scope for the synthesis of different functionally substituted thiochromone scaffolds and can be further exploited to construct diverse thioflavone libraries for pharmaceutical research.
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spelling pubmed-81909242021-06-11 Synthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction Li, Peng Li, Shengnan Li, Gang Huang, Haihong ACS Omega [Image: see text] A concise and efficient cross-coupling synthetic strategy has been developed to construct 2-aryl-4H-thiochromen-4-one derivatives from 2-sulfinyl-thiochromones and arylboronic acids. This reaction proceeds via a catalyst system of Lewis acid and palladium(II) combined with XPhos as an optimal ligand in moderate to good yields. Besides, this flexible methodology provides a wide scope for the synthesis of different functionally substituted thiochromone scaffolds and can be further exploited to construct diverse thioflavone libraries for pharmaceutical research. American Chemical Society 2021-05-21 /pmc/articles/PMC8190924/ /pubmed/34124488 http://dx.doi.org/10.1021/acsomega.1c01778 Text en © 2021 The Authors. Published by American Chemical Society Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Li, Peng
Li, Shengnan
Li, Gang
Huang, Haihong
Synthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction
title Synthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction
title_full Synthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction
title_fullStr Synthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction
title_full_unstemmed Synthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction
title_short Synthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction
title_sort synthesis of 2-aryl-4h-thiochromen-4-one derivatives via a cross-coupling reaction
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190924/
https://www.ncbi.nlm.nih.gov/pubmed/34124488
http://dx.doi.org/10.1021/acsomega.1c01778
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AT huanghaihong synthesisof2aryl4hthiochromen4onederivativesviaacrosscouplingreaction

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