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SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches
SARS-CoV-2 (COVID-19) spreads and develops quickly worldwide as a new global crisis which has left deep socio-economic damage and massive human mortality. This virus accounts for the ongoing outbreak and forces an urgent need to improve antiviral therapeutics and targeted diagnosing tools. Researche...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190993/ https://www.ncbi.nlm.nih.gov/pubmed/34131555 http://dx.doi.org/10.1007/s13204-021-01900-w |
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author | Raja, Ramalingam Karthik Nguyen-Tri, Phuong Balasubramani, Govindasamy Alagarsamy, Arun Hazir, Selcuk Ladhari, Safa Saidi, Alireza Pugazhendhi, Arivalagan Samy, Arulandhu Anthoni |
author_facet | Raja, Ramalingam Karthik Nguyen-Tri, Phuong Balasubramani, Govindasamy Alagarsamy, Arun Hazir, Selcuk Ladhari, Safa Saidi, Alireza Pugazhendhi, Arivalagan Samy, Arulandhu Anthoni |
author_sort | Raja, Ramalingam Karthik |
collection | PubMed |
description | SARS-CoV-2 (COVID-19) spreads and develops quickly worldwide as a new global crisis which has left deep socio-economic damage and massive human mortality. This virus accounts for the ongoing outbreak and forces an urgent need to improve antiviral therapeutics and targeted diagnosing tools. Researchers have been working to find a new drug to combat the virus since the outbreak started in late 2019, but there are currently no successful drugs to control the SARS-CoV-2, which makes the situation riskier. Very recently, new variant of SARS-CoV-2 is identified in many countries which make the situation very critical. No successful treatment has yet been shown although enormous international commitment to combat this pandemic and the start of different clinical trials. Nanomedicine has outstanding potential to solve several specific health issues, like viruses, which are regarded a significant medical issue. In this review, we presented an up-to-date drug design strategy against SARS-CoV-2, including the development of novel drugs and repurposed product potentials were useful, and successful drugs discovery is a constant requirement. The use of nanomaterials in treatment against SARS-CoV-2 and their use as carriers for the transport of the most frequently used antiviral therapeutics are discussed systematically here. We also addressed the possibilities of practical applications of nanoparticles to give the status of COVID-19 antiviral systems. |
format | Online Article Text |
id | pubmed-8190993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-81909932021-06-11 SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches Raja, Ramalingam Karthik Nguyen-Tri, Phuong Balasubramani, Govindasamy Alagarsamy, Arun Hazir, Selcuk Ladhari, Safa Saidi, Alireza Pugazhendhi, Arivalagan Samy, Arulandhu Anthoni Appl Nanosci Review Article SARS-CoV-2 (COVID-19) spreads and develops quickly worldwide as a new global crisis which has left deep socio-economic damage and massive human mortality. This virus accounts for the ongoing outbreak and forces an urgent need to improve antiviral therapeutics and targeted diagnosing tools. Researchers have been working to find a new drug to combat the virus since the outbreak started in late 2019, but there are currently no successful drugs to control the SARS-CoV-2, which makes the situation riskier. Very recently, new variant of SARS-CoV-2 is identified in many countries which make the situation very critical. No successful treatment has yet been shown although enormous international commitment to combat this pandemic and the start of different clinical trials. Nanomedicine has outstanding potential to solve several specific health issues, like viruses, which are regarded a significant medical issue. In this review, we presented an up-to-date drug design strategy against SARS-CoV-2, including the development of novel drugs and repurposed product potentials were useful, and successful drugs discovery is a constant requirement. The use of nanomaterials in treatment against SARS-CoV-2 and their use as carriers for the transport of the most frequently used antiviral therapeutics are discussed systematically here. We also addressed the possibilities of practical applications of nanoparticles to give the status of COVID-19 antiviral systems. Springer International Publishing 2021-06-10 2023 /pmc/articles/PMC8190993/ /pubmed/34131555 http://dx.doi.org/10.1007/s13204-021-01900-w Text en © King Abdulaziz City for Science and Technology 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Raja, Ramalingam Karthik Nguyen-Tri, Phuong Balasubramani, Govindasamy Alagarsamy, Arun Hazir, Selcuk Ladhari, Safa Saidi, Alireza Pugazhendhi, Arivalagan Samy, Arulandhu Anthoni SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches |
title | SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches |
title_full | SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches |
title_fullStr | SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches |
title_full_unstemmed | SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches |
title_short | SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches |
title_sort | sars-cov-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190993/ https://www.ncbi.nlm.nih.gov/pubmed/34131555 http://dx.doi.org/10.1007/s13204-021-01900-w |
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