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SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches

SARS-CoV-2 (COVID-19) spreads and develops quickly worldwide as a new global crisis which has left deep socio-economic damage and massive human mortality. This virus accounts for the ongoing outbreak and forces an urgent need to improve antiviral therapeutics and targeted diagnosing tools. Researche...

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Autores principales: Raja, Ramalingam Karthik, Nguyen-Tri, Phuong, Balasubramani, Govindasamy, Alagarsamy, Arun, Hazir, Selcuk, Ladhari, Safa, Saidi, Alireza, Pugazhendhi, Arivalagan, Samy, Arulandhu Anthoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190993/
https://www.ncbi.nlm.nih.gov/pubmed/34131555
http://dx.doi.org/10.1007/s13204-021-01900-w
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author Raja, Ramalingam Karthik
Nguyen-Tri, Phuong
Balasubramani, Govindasamy
Alagarsamy, Arun
Hazir, Selcuk
Ladhari, Safa
Saidi, Alireza
Pugazhendhi, Arivalagan
Samy, Arulandhu Anthoni
author_facet Raja, Ramalingam Karthik
Nguyen-Tri, Phuong
Balasubramani, Govindasamy
Alagarsamy, Arun
Hazir, Selcuk
Ladhari, Safa
Saidi, Alireza
Pugazhendhi, Arivalagan
Samy, Arulandhu Anthoni
author_sort Raja, Ramalingam Karthik
collection PubMed
description SARS-CoV-2 (COVID-19) spreads and develops quickly worldwide as a new global crisis which has left deep socio-economic damage and massive human mortality. This virus accounts for the ongoing outbreak and forces an urgent need to improve antiviral therapeutics and targeted diagnosing tools. Researchers have been working to find a new drug to combat the virus since the outbreak started in late 2019, but there are currently no successful drugs to control the SARS-CoV-2, which makes the situation riskier. Very recently, new variant of SARS-CoV-2 is identified in many countries which make the situation very critical. No successful treatment has yet been shown although enormous international commitment to combat this pandemic and the start of different clinical trials. Nanomedicine has outstanding potential to solve several specific health issues, like viruses, which are regarded a significant medical issue. In this review, we presented an up-to-date drug design strategy against SARS-CoV-2, including the development of novel drugs and repurposed product potentials were useful, and successful drugs discovery is a constant requirement. The use of nanomaterials in treatment against SARS-CoV-2 and their use as carriers for the transport of the most frequently used antiviral therapeutics are discussed systematically here. We also addressed the possibilities of practical applications of nanoparticles to give the status of COVID-19 antiviral systems.
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spelling pubmed-81909932021-06-11 SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches Raja, Ramalingam Karthik Nguyen-Tri, Phuong Balasubramani, Govindasamy Alagarsamy, Arun Hazir, Selcuk Ladhari, Safa Saidi, Alireza Pugazhendhi, Arivalagan Samy, Arulandhu Anthoni Appl Nanosci Review Article SARS-CoV-2 (COVID-19) spreads and develops quickly worldwide as a new global crisis which has left deep socio-economic damage and massive human mortality. This virus accounts for the ongoing outbreak and forces an urgent need to improve antiviral therapeutics and targeted diagnosing tools. Researchers have been working to find a new drug to combat the virus since the outbreak started in late 2019, but there are currently no successful drugs to control the SARS-CoV-2, which makes the situation riskier. Very recently, new variant of SARS-CoV-2 is identified in many countries which make the situation very critical. No successful treatment has yet been shown although enormous international commitment to combat this pandemic and the start of different clinical trials. Nanomedicine has outstanding potential to solve several specific health issues, like viruses, which are regarded a significant medical issue. In this review, we presented an up-to-date drug design strategy against SARS-CoV-2, including the development of novel drugs and repurposed product potentials were useful, and successful drugs discovery is a constant requirement. The use of nanomaterials in treatment against SARS-CoV-2 and their use as carriers for the transport of the most frequently used antiviral therapeutics are discussed systematically here. We also addressed the possibilities of practical applications of nanoparticles to give the status of COVID-19 antiviral systems. Springer International Publishing 2021-06-10 2023 /pmc/articles/PMC8190993/ /pubmed/34131555 http://dx.doi.org/10.1007/s13204-021-01900-w Text en © King Abdulaziz City for Science and Technology 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Raja, Ramalingam Karthik
Nguyen-Tri, Phuong
Balasubramani, Govindasamy
Alagarsamy, Arun
Hazir, Selcuk
Ladhari, Safa
Saidi, Alireza
Pugazhendhi, Arivalagan
Samy, Arulandhu Anthoni
SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches
title SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches
title_full SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches
title_fullStr SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches
title_full_unstemmed SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches
title_short SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches
title_sort sars-cov-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190993/
https://www.ncbi.nlm.nih.gov/pubmed/34131555
http://dx.doi.org/10.1007/s13204-021-01900-w
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