Cargando…
The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review
BACKGROUND: Tuberculosis (TB) is still one of the leading causes of death worldwide. Genetic studies have pointed to the relevance of the NOD2 and CD14 polymorphic alleles in association with the risk of diseases caused by Mycobacterium tuberculosis (Mtb) infection. METHODS: A systematic review was...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191055/ https://www.ncbi.nlm.nih.gov/pubmed/34108050 http://dx.doi.org/10.1186/s13643-021-01729-y |
_version_ | 1783705801306669056 |
---|---|
author | Cubillos-Angulo, Juan M. Fernandes, Catarina D. Araújo, Davi N. Carmo, Cristinna A. Arriaga, María B. Andrade, Bruno B. |
author_facet | Cubillos-Angulo, Juan M. Fernandes, Catarina D. Araújo, Davi N. Carmo, Cristinna A. Arriaga, María B. Andrade, Bruno B. |
author_sort | Cubillos-Angulo, Juan M. |
collection | PubMed |
description | BACKGROUND: Tuberculosis (TB) is still one of the leading causes of death worldwide. Genetic studies have pointed to the relevance of the NOD2 and CD14 polymorphic alleles in association with the risk of diseases caused by Mycobacterium tuberculosis (Mtb) infection. METHODS: A systematic review was performed on PubMed, EMBASE, Scientific Electronic Library Online (SciELO), and Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) to examine the association between single nucleotide polymorphisms (SNP) and risk of Mtb diseases. Study quality was evaluated using the Newcastle-Ottawa Quality Scale (NOQS), and the linkage disequilibrium was calculated for all SNPs using a webtool (Package LDpop). RESULTS: Thirteen studies matched the selection criteria. Of those, 9 investigated CD14 SNPs, and 6 reported a significant association between the T allele and TT genotypes of the rs2569190 SNP and increased risk of Mtb diseases. The genotype CC was found to be protective against TB disease. Furthermore, in two studies, the CD14 rs2569191 SNP with the G allele was significantly associated with increased risk of Mtb diseases. Four studies reported data uncovering the relationship between NOD2 SNPs and risk of Mtb diseases, with two reporting significant associations of rs1861759 and rs7194886 and higher risk of Mtb diseases in a Chinese Han population. Paradoxically, minor allele carriers (CG or GG) of rs2066842 and rs2066844 NOD2 SNPs were associated with lower risk of Mtb diseases in African Americans. CONCLUSIONS: The CD14 rs2569190 and rs2569191 polymorphisms may influence risk of Mtb diseases depending on the allele. Furthermore, there is significant association between NOD2 SNPs rs1861759 and rs7194886 and augmented risk of Mtb diseases, especially in persons of Chinese ethnicity. The referred polymorphisms of CD14 and NOD2 genes likely play an important role in risk of Mtb diseases and pathology and may be affected by ethnicity. SYSTEMATIC REVIEW REGISTRATION: CRD42020186523 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-021-01729-y. |
format | Online Article Text |
id | pubmed-8191055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81910552021-06-10 The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review Cubillos-Angulo, Juan M. Fernandes, Catarina D. Araújo, Davi N. Carmo, Cristinna A. Arriaga, María B. Andrade, Bruno B. Syst Rev Research BACKGROUND: Tuberculosis (TB) is still one of the leading causes of death worldwide. Genetic studies have pointed to the relevance of the NOD2 and CD14 polymorphic alleles in association with the risk of diseases caused by Mycobacterium tuberculosis (Mtb) infection. METHODS: A systematic review was performed on PubMed, EMBASE, Scientific Electronic Library Online (SciELO), and Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) to examine the association between single nucleotide polymorphisms (SNP) and risk of Mtb diseases. Study quality was evaluated using the Newcastle-Ottawa Quality Scale (NOQS), and the linkage disequilibrium was calculated for all SNPs using a webtool (Package LDpop). RESULTS: Thirteen studies matched the selection criteria. Of those, 9 investigated CD14 SNPs, and 6 reported a significant association between the T allele and TT genotypes of the rs2569190 SNP and increased risk of Mtb diseases. The genotype CC was found to be protective against TB disease. Furthermore, in two studies, the CD14 rs2569191 SNP with the G allele was significantly associated with increased risk of Mtb diseases. Four studies reported data uncovering the relationship between NOD2 SNPs and risk of Mtb diseases, with two reporting significant associations of rs1861759 and rs7194886 and higher risk of Mtb diseases in a Chinese Han population. Paradoxically, minor allele carriers (CG or GG) of rs2066842 and rs2066844 NOD2 SNPs were associated with lower risk of Mtb diseases in African Americans. CONCLUSIONS: The CD14 rs2569190 and rs2569191 polymorphisms may influence risk of Mtb diseases depending on the allele. Furthermore, there is significant association between NOD2 SNPs rs1861759 and rs7194886 and augmented risk of Mtb diseases, especially in persons of Chinese ethnicity. The referred polymorphisms of CD14 and NOD2 genes likely play an important role in risk of Mtb diseases and pathology and may be affected by ethnicity. SYSTEMATIC REVIEW REGISTRATION: CRD42020186523 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-021-01729-y. BioMed Central 2021-06-09 /pmc/articles/PMC8191055/ /pubmed/34108050 http://dx.doi.org/10.1186/s13643-021-01729-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Cubillos-Angulo, Juan M. Fernandes, Catarina D. Araújo, Davi N. Carmo, Cristinna A. Arriaga, María B. Andrade, Bruno B. The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review |
title | The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review |
title_full | The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review |
title_fullStr | The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review |
title_full_unstemmed | The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review |
title_short | The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review |
title_sort | influence of single nucleotide polymorphisms of nod2 or cd14 on the risk of mycobacterium tuberculosis diseases: a systematic review |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191055/ https://www.ncbi.nlm.nih.gov/pubmed/34108050 http://dx.doi.org/10.1186/s13643-021-01729-y |
work_keys_str_mv | AT cubillosangulojuanm theinfluenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview AT fernandescatarinad theinfluenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview AT araujodavin theinfluenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview AT carmocristinnaa theinfluenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview AT arriagamariab theinfluenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview AT andradebrunob theinfluenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview AT cubillosangulojuanm influenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview AT fernandescatarinad influenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview AT araujodavin influenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview AT carmocristinnaa influenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview AT arriagamariab influenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview AT andradebrunob influenceofsinglenucleotidepolymorphismsofnod2orcd14ontheriskofmycobacteriumtuberculosisdiseasesasystematicreview |