MiR-223 or miR-126 predicts resistance to dual antiplatelet therapy in patients with ST-elevation myocardial infarction

OBJECTIVE: To explore the role of miR-223 and miR-126 in predicting treatment responses to dual antiplatelet therapy (DAPT) in patients with ST-elevation myocardial infarction (STEMI). METHODS: Plasma miR-223 and miR-126 levels were measured before treatment. Treatment responses and 2-year survival...

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Autores principales: Li, Xiaojing, Yao, Qi, Cui, Hanbin, Yang, Jun, Wu, Nan, Liu, Yahui, Zhou, Ying, Zhang, Yinwei, Su, Jia, Xia, Yezi, Chen, Xiaomin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Retrospective Clinical Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191085/
https://www.ncbi.nlm.nih.gov/pubmed/34098766
http://dx.doi.org/10.1177/03000605211016209
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author Li, Xiaojing
Yao, Qi
Cui, Hanbin
Yang, Jun
Wu, Nan
Liu, Yahui
Zhou, Ying
Zhang, Yinwei
Su, Jia
Xia, Yezi
Chen, Xiaomin
author_facet Li, Xiaojing
Yao, Qi
Cui, Hanbin
Yang, Jun
Wu, Nan
Liu, Yahui
Zhou, Ying
Zhang, Yinwei
Su, Jia
Xia, Yezi
Chen, Xiaomin
author_sort Li, Xiaojing
collection PubMed
description OBJECTIVE: To explore the role of miR-223 and miR-126 in predicting treatment responses to dual antiplatelet therapy (DAPT) in patients with ST-elevation myocardial infarction (STEMI). METHODS: Plasma miR-223 and miR-126 levels were measured before treatment. Treatment responses and 2-year survival were determined. In vitro experiments were performed to explore the mechanism of action. RESULTS: Patients with resistance to DAPT had a lower level of miR-223 and miR-126. Cardiac-event-free survival was shorter in patients with lower miR-223 or miR-126 levels. MiR-223 and miR-126 independently predicted DAPT resistance. Modulating miR-223 or miR-126 in platelets in vitro significantly changed the response to clopidogrel by regulating platelet aggregation. CONCLUSION: MiR-223 and miR-126 play a role in DAPT resistance and may provide potential biomarkers in patients with STEMI.
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spelling pubmed-81910852021-06-22 MiR-223 or miR-126 predicts resistance to dual antiplatelet therapy in patients with ST-elevation myocardial infarction Li, Xiaojing Yao, Qi Cui, Hanbin Yang, Jun Wu, Nan Liu, Yahui Zhou, Ying Zhang, Yinwei Su, Jia Xia, Yezi Chen, Xiaomin J Int Med Res Retrospective Clinical Research Report OBJECTIVE: To explore the role of miR-223 and miR-126 in predicting treatment responses to dual antiplatelet therapy (DAPT) in patients with ST-elevation myocardial infarction (STEMI). METHODS: Plasma miR-223 and miR-126 levels were measured before treatment. Treatment responses and 2-year survival were determined. In vitro experiments were performed to explore the mechanism of action. RESULTS: Patients with resistance to DAPT had a lower level of miR-223 and miR-126. Cardiac-event-free survival was shorter in patients with lower miR-223 or miR-126 levels. MiR-223 and miR-126 independently predicted DAPT resistance. Modulating miR-223 or miR-126 in platelets in vitro significantly changed the response to clopidogrel by regulating platelet aggregation. CONCLUSION: MiR-223 and miR-126 play a role in DAPT resistance and may provide potential biomarkers in patients with STEMI. SAGE Publications 2021-06-07 /pmc/articles/PMC8191085/ /pubmed/34098766 http://dx.doi.org/10.1177/03000605211016209 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Li, Xiaojing
Yao, Qi
Cui, Hanbin
Yang, Jun
Wu, Nan
Liu, Yahui
Zhou, Ying
Zhang, Yinwei
Su, Jia
Xia, Yezi
Chen, Xiaomin
MiR-223 or miR-126 predicts resistance to dual antiplatelet therapy in patients with ST-elevation myocardial infarction
title MiR-223 or miR-126 predicts resistance to dual antiplatelet therapy in patients with ST-elevation myocardial infarction
title_full MiR-223 or miR-126 predicts resistance to dual antiplatelet therapy in patients with ST-elevation myocardial infarction
title_fullStr MiR-223 or miR-126 predicts resistance to dual antiplatelet therapy in patients with ST-elevation myocardial infarction
title_full_unstemmed MiR-223 or miR-126 predicts resistance to dual antiplatelet therapy in patients with ST-elevation myocardial infarction
title_short MiR-223 or miR-126 predicts resistance to dual antiplatelet therapy in patients with ST-elevation myocardial infarction
title_sort mir-223 or mir-126 predicts resistance to dual antiplatelet therapy in patients with st-elevation myocardial infarction
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191085/
https://www.ncbi.nlm.nih.gov/pubmed/34098766
http://dx.doi.org/10.1177/03000605211016209
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