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ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes

BACKGROUND: Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or poor prognosis, but the underlying mechanisms are largely unknown. The limonoid...

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Detalles Bibliográficos
Autores principales:	Yu, Fang, Gajendran, Babu, Wang, Ning, Sample, Klarke M., Liu, Wuling, Wang, Chunlin, Hu, Anling, Zacksenhaus, Eldad, Hao, Xiaojiang, Ben-David, Yaacov
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191108/ https://www.ncbi.nlm.nih.gov/pubmed/34107900 http://dx.doi.org/10.1186/s12885-021-08402-6

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