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CR3 ruffles FcγR’s claim over phagocytic cups
Phagocytosis plays diverse roles in biology, but our understanding of the purpose, interplay, and cell signaling mechanisms associated with different modes of phagocytosis is limited, without being able to capture and visualize each step in this rapid process from the beginning to end. A new study b...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191298/ https://www.ncbi.nlm.nih.gov/pubmed/34019878 http://dx.doi.org/10.1016/j.jbc.2021.100801 |
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author | Frautschy, S.A. |
author_facet | Frautschy, S.A. |
author_sort | Frautschy, S.A. |
collection | PubMed |
description | Phagocytosis plays diverse roles in biology, but our understanding of the purpose, interplay, and cell signaling mechanisms associated with different modes of phagocytosis is limited, without being able to capture and visualize each step in this rapid process from the beginning to end. A new study by Walbaum et al. uses stunning time-lapse 3D imaging of the engulfment of erythrocytes by macrophages via sinking, ruffling, and cup formation, unequivocally confirming a visionary 44-year-old theory derived from still electron microscopy photos that phagocytosis mediated by complement receptor CR3 occurs via a sinking mechanism and antibody-mediated phagocytosis occurs via phagocytic cup formation. The article also challenges the dogma, showing that phagocytic cup formation is not unique to antibody receptor phagocytosis, rather CR3 plays a complex role in different modes of phagocytosis. For example, inhibition of antibody-mediated phagocytosis leads to a compensatory upregulation of CR3-mediated sinking phagocytosis. These findings animate, in vivid colors, processes previously only captured as stills, exposing interactions between different phagocytic mechanisms and altering our basic understanding of this important process. |
format | Online Article Text |
id | pubmed-8191298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-81912982021-06-16 CR3 ruffles FcγR’s claim over phagocytic cups Frautschy, S.A. J Biol Chem Editors' Pick Highlight Phagocytosis plays diverse roles in biology, but our understanding of the purpose, interplay, and cell signaling mechanisms associated with different modes of phagocytosis is limited, without being able to capture and visualize each step in this rapid process from the beginning to end. A new study by Walbaum et al. uses stunning time-lapse 3D imaging of the engulfment of erythrocytes by macrophages via sinking, ruffling, and cup formation, unequivocally confirming a visionary 44-year-old theory derived from still electron microscopy photos that phagocytosis mediated by complement receptor CR3 occurs via a sinking mechanism and antibody-mediated phagocytosis occurs via phagocytic cup formation. The article also challenges the dogma, showing that phagocytic cup formation is not unique to antibody receptor phagocytosis, rather CR3 plays a complex role in different modes of phagocytosis. For example, inhibition of antibody-mediated phagocytosis leads to a compensatory upregulation of CR3-mediated sinking phagocytosis. These findings animate, in vivid colors, processes previously only captured as stills, exposing interactions between different phagocytic mechanisms and altering our basic understanding of this important process. American Society for Biochemistry and Molecular Biology 2021-05-19 /pmc/articles/PMC8191298/ /pubmed/34019878 http://dx.doi.org/10.1016/j.jbc.2021.100801 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editors' Pick Highlight Frautschy, S.A. CR3 ruffles FcγR’s claim over phagocytic cups |
title | CR3 ruffles FcγR’s claim over phagocytic cups |
title_full | CR3 ruffles FcγR’s claim over phagocytic cups |
title_fullStr | CR3 ruffles FcγR’s claim over phagocytic cups |
title_full_unstemmed | CR3 ruffles FcγR’s claim over phagocytic cups |
title_short | CR3 ruffles FcγR’s claim over phagocytic cups |
title_sort | cr3 ruffles fcγr’s claim over phagocytic cups |
topic | Editors' Pick Highlight |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191298/ https://www.ncbi.nlm.nih.gov/pubmed/34019878 http://dx.doi.org/10.1016/j.jbc.2021.100801 |
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