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A comprehensive mechanism for 5-carboxylcytosine-induced transcriptional pausing revealed by Markov state models

RNA polymerase II (Pol II) surveils the genome, pausing as it encounters DNA lesions and base modifications and initiating signals for DNA repair among other important regulatory events. Recent work suggests that Pol II pauses at 5-carboxycytosine (5caC), an epigenetic modification of cytosine, beca...

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Detalles Bibliográficos
Autores principales:	Konovalov, Kirill A., Wang, Wei, Wang, Guo, Goonetilleke, Eshani C., Gao, Xin, Wang, Dong, Huang, Xuhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191312/ https://www.ncbi.nlm.nih.gov/pubmed/33991521 http://dx.doi.org/10.1016/j.jbc.2021.100735

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