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TBK1 interacts with tau and enhances neurodegeneration in tauopathy

One of the defining pathological features of Alzheimer’s disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau in the brain. Aberrant activation of kinases in AD has been suggested to enhance phosphorylation and toxicity of tau, making the responsible t...

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Detalles Bibliográficos
Autores principales:	Abreha, Measho H., Ojelade, Shamsideen, Dammer, Eric B., McEachin, Zachary T., Duong, Duc M., Gearing, Marla, Bassell, Gary J., Lah, James J., Levey, Allan I., Shulman, Joshua M., Seyfried, Nicholas T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191334/ https://www.ncbi.nlm.nih.gov/pubmed/33965374 http://dx.doi.org/10.1016/j.jbc.2021.100760

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