An alginate-confined peroxygenase-CLEA for styrene epoxidation

Oxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatal...

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Detalles Bibliográficos
Autores principales: Nintzel, Friederike E. H., Wu, Yinqi, Planchestainer, Matteo, Held, Martin, Alcalde, Miguel, Hollmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191455/
https://www.ncbi.nlm.nih.gov/pubmed/33987632
http://dx.doi.org/10.1039/d1cc01868j
Descripción
Sumario:Oxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM.

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