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(18)F-FDG PET/CT imaging features of patients with multicentric Castleman disease

The aim of this study is to investigate the role of (18)F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) in the evaluation of multicentric Castleman disease (MCD). METHODS: Thirty-five patients with pathologically confirmed MCD who underwent (18)F-FDG PET/CT were retrospectively included. The...

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Autores principales: Jiang, Yuanyuan, Hou, Guozhu, Zhu, Zhaohui, Huo, Li, Li, Fang, Cheng, Wuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191470/
https://www.ncbi.nlm.nih.gov/pubmed/33741858
http://dx.doi.org/10.1097/MNM.0000000000001404
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author Jiang, Yuanyuan
Hou, Guozhu
Zhu, Zhaohui
Huo, Li
Li, Fang
Cheng, Wuying
author_facet Jiang, Yuanyuan
Hou, Guozhu
Zhu, Zhaohui
Huo, Li
Li, Fang
Cheng, Wuying
author_sort Jiang, Yuanyuan
collection PubMed
description The aim of this study is to investigate the role of (18)F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) in the evaluation of multicentric Castleman disease (MCD). METHODS: Thirty-five patients with pathologically confirmed MCD who underwent (18)F-FDG PET/CT were retrospectively included. The FDG uptake and CT findings of lymph nodes, pulmonary involvement, spleen, and bone marrow were assessed and the maximum standardized uptake value (SUVmax) of each lesion was measured. The locations of lymph nodes were also evaluated. RESULTS: (18)F-FDG PET/CT showed increased uptake in multiple nodal regions in 34 out of 35 MCD patients. The most frequently involved nodal sites were the cervical, iliac, axillary, and inguinal areas, and the least common was paraaortic and abdominal nodes. The involved lymph nodes were not confluent and presented a relatively symmetric pattern on PET/CT images. The highest SUVmax of lymph nodes per patient ranged from 2 to 19 with a mean value of 5.61 ± 3.12. Pulmonary manifestation including cysts, nodules, and interstitial lung disease were found in 10 patients, eight of whom demonstrated mild to moderate uptake in the lungs. (18)F-FDG PET/CT also revealed other findings including hypermetabolic spleen (n = 8) and bone marrow (n = 23), elevated uptake in salivary glands (n = 8). Four patients also underwent follow-up PET/CT scans after therapy, and three of them displayed decreased metabolism. CONCLUSION: (18)F-FDG PET/CT is a useful tool in the diagnosis, evaluation, and follow-up of MCD by providing systemic manifestations of lymphadenopathy, pulmonary involvement, and hypermetabolic spleen or bone marrow. Furthermore, the lymphadenopathy in MCD presented a predominantly peripheral distribution, relatively symmetric, moderately hypermetabolic, and not confluent pattern on (18)F-FDG PET/CT.
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spelling pubmed-81914702021-06-16 (18)F-FDG PET/CT imaging features of patients with multicentric Castleman disease Jiang, Yuanyuan Hou, Guozhu Zhu, Zhaohui Huo, Li Li, Fang Cheng, Wuying Nucl Med Commun Original Articles The aim of this study is to investigate the role of (18)F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) in the evaluation of multicentric Castleman disease (MCD). METHODS: Thirty-five patients with pathologically confirmed MCD who underwent (18)F-FDG PET/CT were retrospectively included. The FDG uptake and CT findings of lymph nodes, pulmonary involvement, spleen, and bone marrow were assessed and the maximum standardized uptake value (SUVmax) of each lesion was measured. The locations of lymph nodes were also evaluated. RESULTS: (18)F-FDG PET/CT showed increased uptake in multiple nodal regions in 34 out of 35 MCD patients. The most frequently involved nodal sites were the cervical, iliac, axillary, and inguinal areas, and the least common was paraaortic and abdominal nodes. The involved lymph nodes were not confluent and presented a relatively symmetric pattern on PET/CT images. The highest SUVmax of lymph nodes per patient ranged from 2 to 19 with a mean value of 5.61 ± 3.12. Pulmonary manifestation including cysts, nodules, and interstitial lung disease were found in 10 patients, eight of whom demonstrated mild to moderate uptake in the lungs. (18)F-FDG PET/CT also revealed other findings including hypermetabolic spleen (n = 8) and bone marrow (n = 23), elevated uptake in salivary glands (n = 8). Four patients also underwent follow-up PET/CT scans after therapy, and three of them displayed decreased metabolism. CONCLUSION: (18)F-FDG PET/CT is a useful tool in the diagnosis, evaluation, and follow-up of MCD by providing systemic manifestations of lymphadenopathy, pulmonary involvement, and hypermetabolic spleen or bone marrow. Furthermore, the lymphadenopathy in MCD presented a predominantly peripheral distribution, relatively symmetric, moderately hypermetabolic, and not confluent pattern on (18)F-FDG PET/CT. Lippincott Williams & Wilkins 2021-03-18 2021-07 /pmc/articles/PMC8191470/ /pubmed/33741858 http://dx.doi.org/10.1097/MNM.0000000000001404 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Articles
Jiang, Yuanyuan
Hou, Guozhu
Zhu, Zhaohui
Huo, Li
Li, Fang
Cheng, Wuying
(18)F-FDG PET/CT imaging features of patients with multicentric Castleman disease
title (18)F-FDG PET/CT imaging features of patients with multicentric Castleman disease
title_full (18)F-FDG PET/CT imaging features of patients with multicentric Castleman disease
title_fullStr (18)F-FDG PET/CT imaging features of patients with multicentric Castleman disease
title_full_unstemmed (18)F-FDG PET/CT imaging features of patients with multicentric Castleman disease
title_short (18)F-FDG PET/CT imaging features of patients with multicentric Castleman disease
title_sort (18)f-fdg pet/ct imaging features of patients with multicentric castleman disease
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191470/
https://www.ncbi.nlm.nih.gov/pubmed/33741858
http://dx.doi.org/10.1097/MNM.0000000000001404
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