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Case Report: Circulating Myeloid-Derived Suppressive-Like Cells and Exhausted Immune Cells in Non-Small Cell Lung Cancer Patients Treated With Three Immune Checkpoint Inhibitors

Immune checkpoint inhibition induced a great step forward in the treatment of non-small cell lung cancer patients. In cancer immune microenvironment many checkpoints were studied and their involvement could represent a mechanism of resistance to cancer immunotherapy. For this reason, the inhibition...

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Autores principales: Bronte, Giuseppe, Verlicchi, Alberto, De Matteis, Serena, Rossi, Alice, Affatato, Alessandra, Sullo, Francesco Giulio, Gianni, Caterina, Canale, Matteo, Burgio, Marco Angelo, Delmonte, Angelo, Milella, Michele, Crinò, Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191501/
https://www.ncbi.nlm.nih.gov/pubmed/34122429
http://dx.doi.org/10.3389/fimmu.2021.672219
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author Bronte, Giuseppe
Verlicchi, Alberto
De Matteis, Serena
Rossi, Alice
Affatato, Alessandra
Sullo, Francesco Giulio
Gianni, Caterina
Canale, Matteo
Burgio, Marco Angelo
Delmonte, Angelo
Milella, Michele
Crinò, Lucio
author_facet Bronte, Giuseppe
Verlicchi, Alberto
De Matteis, Serena
Rossi, Alice
Affatato, Alessandra
Sullo, Francesco Giulio
Gianni, Caterina
Canale, Matteo
Burgio, Marco Angelo
Delmonte, Angelo
Milella, Michele
Crinò, Lucio
author_sort Bronte, Giuseppe
collection PubMed
description Immune checkpoint inhibition induced a great step forward in the treatment of non-small cell lung cancer patients. In cancer immune microenvironment many checkpoints were studied and their involvement could represent a mechanism of resistance to cancer immunotherapy. For this reason, the inhibition of multiple immune checkpoints is under development. However, myeloid-derived suppressor cells (MDSC) and exhausted immune cells could limit the efficacy of cancer immunotherapy. We analyzed the variation of circulating immune suppressive-like cell subsets and exhausted immune cells in three non-small cell lung cancer patients treated with the combination of anti-CTLA-4 plus anti-PD-1 plus anti-LAG-3 at T0 (baseline), T1 (after 2 months) and T2 (after 4 months). We also describe the clinical and radiological course of the disease during this treatment in all three patients. We observed both clinical differences and changes in the composition of immune suppressive-like cell subsets and exhausted immune cells between the patients receiving the same schedule of treatment with immune checkpoint inhibitors. The study on a wider patient population and experimental model design could help to clarify the kinetics of these cell subpopulations with the perspective to find new targets for treatment or new biomarkers for resistance to cancer immunotherapy.
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spelling pubmed-81915012021-06-11 Case Report: Circulating Myeloid-Derived Suppressive-Like Cells and Exhausted Immune Cells in Non-Small Cell Lung Cancer Patients Treated With Three Immune Checkpoint Inhibitors Bronte, Giuseppe Verlicchi, Alberto De Matteis, Serena Rossi, Alice Affatato, Alessandra Sullo, Francesco Giulio Gianni, Caterina Canale, Matteo Burgio, Marco Angelo Delmonte, Angelo Milella, Michele Crinò, Lucio Front Immunol Immunology Immune checkpoint inhibition induced a great step forward in the treatment of non-small cell lung cancer patients. In cancer immune microenvironment many checkpoints were studied and their involvement could represent a mechanism of resistance to cancer immunotherapy. For this reason, the inhibition of multiple immune checkpoints is under development. However, myeloid-derived suppressor cells (MDSC) and exhausted immune cells could limit the efficacy of cancer immunotherapy. We analyzed the variation of circulating immune suppressive-like cell subsets and exhausted immune cells in three non-small cell lung cancer patients treated with the combination of anti-CTLA-4 plus anti-PD-1 plus anti-LAG-3 at T0 (baseline), T1 (after 2 months) and T2 (after 4 months). We also describe the clinical and radiological course of the disease during this treatment in all three patients. We observed both clinical differences and changes in the composition of immune suppressive-like cell subsets and exhausted immune cells between the patients receiving the same schedule of treatment with immune checkpoint inhibitors. The study on a wider patient population and experimental model design could help to clarify the kinetics of these cell subpopulations with the perspective to find new targets for treatment or new biomarkers for resistance to cancer immunotherapy. Frontiers Media S.A. 2021-05-27 /pmc/articles/PMC8191501/ /pubmed/34122429 http://dx.doi.org/10.3389/fimmu.2021.672219 Text en Copyright © 2021 Bronte, Verlicchi, De Matteis, Rossi, Affatato, Sullo, Gianni, Canale, Burgio, Delmonte, Milella and Crinò https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Bronte, Giuseppe
Verlicchi, Alberto
De Matteis, Serena
Rossi, Alice
Affatato, Alessandra
Sullo, Francesco Giulio
Gianni, Caterina
Canale, Matteo
Burgio, Marco Angelo
Delmonte, Angelo
Milella, Michele
Crinò, Lucio
Case Report: Circulating Myeloid-Derived Suppressive-Like Cells and Exhausted Immune Cells in Non-Small Cell Lung Cancer Patients Treated With Three Immune Checkpoint Inhibitors
title Case Report: Circulating Myeloid-Derived Suppressive-Like Cells and Exhausted Immune Cells in Non-Small Cell Lung Cancer Patients Treated With Three Immune Checkpoint Inhibitors
title_full Case Report: Circulating Myeloid-Derived Suppressive-Like Cells and Exhausted Immune Cells in Non-Small Cell Lung Cancer Patients Treated With Three Immune Checkpoint Inhibitors
title_fullStr Case Report: Circulating Myeloid-Derived Suppressive-Like Cells and Exhausted Immune Cells in Non-Small Cell Lung Cancer Patients Treated With Three Immune Checkpoint Inhibitors
title_full_unstemmed Case Report: Circulating Myeloid-Derived Suppressive-Like Cells and Exhausted Immune Cells in Non-Small Cell Lung Cancer Patients Treated With Three Immune Checkpoint Inhibitors
title_short Case Report: Circulating Myeloid-Derived Suppressive-Like Cells and Exhausted Immune Cells in Non-Small Cell Lung Cancer Patients Treated With Three Immune Checkpoint Inhibitors
title_sort case report: circulating myeloid-derived suppressive-like cells and exhausted immune cells in non-small cell lung cancer patients treated with three immune checkpoint inhibitors
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191501/
https://www.ncbi.nlm.nih.gov/pubmed/34122429
http://dx.doi.org/10.3389/fimmu.2021.672219
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