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A case report: paroxysmal nocturnal hemoglobinuria and systemic lupus erythematosus association
Paroxysmal nocturnal hemoglobinuria (PNH) is defined by acquired intravascular hemolytic anemia, thrombosis and bone marrow failure with pancytopenia. Systemic lupus erythematosus (SLE) also appears as an autoimmune disease. The coexistence of both is rarely reported. Here we report the case of a 30...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Future Medicine Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191648/ https://www.ncbi.nlm.nih.gov/pubmed/34136122 http://dx.doi.org/10.2217/ijh-2020-0013 |
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author | Serin, Istemi Bayir, Aslıhan Goze, Hasan Yokus, Osman |
author_facet | Serin, Istemi Bayir, Aslıhan Goze, Hasan Yokus, Osman |
author_sort | Serin, Istemi |
collection | PubMed |
description | Paroxysmal nocturnal hemoglobinuria (PNH) is defined by acquired intravascular hemolytic anemia, thrombosis and bone marrow failure with pancytopenia. Systemic lupus erythematosus (SLE) also appears as an autoimmune disease. The coexistence of both is rarely reported. Here we report the case of a 30-year-old female presenting with pancytopenia and diagnosed as SLE, who also had a PNH clone. Bone marrow biopsy did not support hypoplastic anemia. The patient was then followed up with the consideration of the existence of a PNH clone with SLE. She was treated by the rheumatology department and complete blood count improved under immunosuppressive treatment. The coexistence of CD59–CD55 deficiency with autoimmune diseases has been reported. It is an important example in terms of receiving clinical response with SLE-specific treatment. |
format | Online Article Text |
id | pubmed-8191648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Future Medicine Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-81916482021-06-15 A case report: paroxysmal nocturnal hemoglobinuria and systemic lupus erythematosus association Serin, Istemi Bayir, Aslıhan Goze, Hasan Yokus, Osman Int J Hematol Oncol Case Report Paroxysmal nocturnal hemoglobinuria (PNH) is defined by acquired intravascular hemolytic anemia, thrombosis and bone marrow failure with pancytopenia. Systemic lupus erythematosus (SLE) also appears as an autoimmune disease. The coexistence of both is rarely reported. Here we report the case of a 30-year-old female presenting with pancytopenia and diagnosed as SLE, who also had a PNH clone. Bone marrow biopsy did not support hypoplastic anemia. The patient was then followed up with the consideration of the existence of a PNH clone with SLE. She was treated by the rheumatology department and complete blood count improved under immunosuppressive treatment. The coexistence of CD59–CD55 deficiency with autoimmune diseases has been reported. It is an important example in terms of receiving clinical response with SLE-specific treatment. Future Medicine Ltd 2020-11-13 /pmc/articles/PMC8191648/ /pubmed/34136122 http://dx.doi.org/10.2217/ijh-2020-0013 Text en © 2020 Istemi Serin https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Case Report Serin, Istemi Bayir, Aslıhan Goze, Hasan Yokus, Osman A case report: paroxysmal nocturnal hemoglobinuria and systemic lupus erythematosus association |
title | A case report: paroxysmal nocturnal hemoglobinuria and systemic lupus erythematosus association |
title_full | A case report: paroxysmal nocturnal hemoglobinuria and systemic lupus erythematosus association |
title_fullStr | A case report: paroxysmal nocturnal hemoglobinuria and systemic lupus erythematosus association |
title_full_unstemmed | A case report: paroxysmal nocturnal hemoglobinuria and systemic lupus erythematosus association |
title_short | A case report: paroxysmal nocturnal hemoglobinuria and systemic lupus erythematosus association |
title_sort | case report: paroxysmal nocturnal hemoglobinuria and systemic lupus erythematosus association |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191648/ https://www.ncbi.nlm.nih.gov/pubmed/34136122 http://dx.doi.org/10.2217/ijh-2020-0013 |
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