Cargando…

Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence

The hexanucleotide repeat expansion, GGGGCC (G4C2), within the first intron of the C9orf72 gene is known to be the most common genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The G4C2 repeat expansions, either DNA or RNA, are able to form G-quadruplexes w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geng, Yanyan, Liu, Changdong, Cai, Qixu, Luo, Zhipu, Miao, Haitao, Shi, Xiao, Xu, Naining, Fung, Chun Po, Choy, To To, Yan, Bing, Li, Ning, Qian, Peiyuan, Zhou, Bo, Zhu, Guang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191786/ https://www.ncbi.nlm.nih.gov/pubmed/34048588 http://dx.doi.org/10.1093/nar/gkab302

Ejemplares similares

Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence
por: Zhou, Bo, et al.
Publicado: (2018)

The crystal structure of an antiparallel chair-type G-quadruplex formed by Bromo-substituted human telomeric DNA
por: Geng, Yanyan, et al.
Publicado: (2019)

Solution structure of a DNA quadruplex containing ALS and FTD related GGGGCC repeat stabilized by 8-bromodeoxyguanosine substitution
por: Brčić, Jasna, et al.
Publicado: (2015)

Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD
por: Zhou, Bo, et al.
Publicado: (2015)

Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA
por: Xu, Naining, et al.
Publicado: (2020)

Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8•(GGCCCC)8 repeat: effect of CpG methylation
por: Zamiri, Bita, et al.
Publicado: (2015)

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD
por: Fujino, Yuzo, et al.
Publicado: (2023)

The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD
por: He, Fang, et al.
Publicado: (2020)

Selective C9orf72 G-Quadruplex-Binding Small Molecules Ameliorate Pathological Signatures of ALS/FTD Models
por: Cheng, Aifang, et al.
Publicado: (2022)

The first crystal structures of hybrid and parallel four-tetrad intramolecular G-quadruplexes
por: Beseiso, Dana, et al.
Publicado: (2022)

Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.
por: Goodman, Lindsey D., et al.
Publicado: (2019)

The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions
por: Hänsel, Robert, et al.
Publicado: (2011)

A Peptidylic Inhibitor for Neutralizing (r)(GGGGCC)(exp)-Associated Neurodegeneration in C9ALS-FTD
por: Zhang, Qian, et al.
Publicado: (2019)

Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes
por: Dickerhoff, Jonathan, et al.
Publicado: (2021)

The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages
por: Clark, George R., et al.
Publicado: (2012)

The hTERT core promoter forms three parallel G-quadruplexes
por: Monsen, Robert C, et al.
Publicado: (2020)

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K(+): insights into loop interactions of the parallel G-quadruplexes
por: Agrawal, Prashansa, et al.
Publicado: (2013)

G-Quadruplexes Formation by the C9orf72 Nucleotide Repeat Expansion d(GGGGCC)(n) and Conformation Regulation by Fangchinoline
por: Zhang, Yun, et al.
Publicado: (2023)

Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD
por: Yuva-Aydemir, Yeliz, et al.
Publicado: (2019)

NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes
por: Winnerdy, Fernaldo Richtia, et al.
Publicado: (2019)

The beginning and the end: flanking nucleotides induce a parallel G-quadruplex topology
por: Chen, Jielin, et al.
Publicado: (2021)

Mechanical diversity and folding intermediates of parallel-stranded G-quadruplexes with a bulge
por: Zhang, Yashuo, et al.
Publicado: (2021)

Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex
por: Gill, Michelle L., et al.
Publicado: (2006)

Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
por: Tong, Xiaotian, et al.
Publicado: (2011)

c-MYC promoter G-quadruplex formed at the 5′-end of NHE III(1) element: insights into biological relevance and parallel-stranded G-quadruplex stability
por: Mathad, Raveendra I., et al.
Publicado: (2011)

A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K(+) solution
por: Liu, Changdong, et al.
Publicado: (2018)

Quadruplexes in ‘Dicty’: crystal structure of a four-quartet G-quadruplex formed by G-rich motif found in the Dictyostelium discoideum genome
por: Guédin, Aurore, et al.
Publicado: (2018)

Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes
por: Cang, Xiaohui, et al.
Publicado: (2011)

Distinctive structural motifs of RNA G-quadruplexes composed of AGG, CGG and UGG trinucleotide repeats
por: Malgowska, Magdalena, et al.
Publicado: (2014)

Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome
por: De Nicola, Beatrice, et al.
Publicado: (2016)

Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia
por: Fratta, Pietro, et al.
Publicado: (2013)

DNA Replication Dynamics of the GGGGCC Repeat of the C9orf72 Gene
por: Thys, Ryan Griffin, et al.
Publicado: (2015)

Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter
por: Kuryavyi, Vitaly, et al.
Publicado: (2010)

Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation
por: Cian, Anne De, et al.
Publicado: (2007)

Direct experimental evidence for quadruplex–quadruplex interaction within the human ILPR
por: Schonhoft, Joseph D., et al.
Publicado: (2009)

A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes
por: Wang, Zi-Fu, et al.
Publicado: (2016)

Crystal structure of a DNA/Ba(2+) G-quadruplex containing a water-mediated C-tetrad
por: Zhang, Diana, et al.
Publicado: (2014)

NMR structure of a G-quadruplex formed by four d(G(4)C(2)) repeats: insights into structural polymorphism
por: Brčić, Jasna, et al.
Publicado: (2018)

A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD
por: Hukema, Renate K, et al.
Publicado: (2014)

Natural isoflavones regulate the quadruplex–duplex competition in human telomeric DNA
por: Zhang, Jin-li, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_jjr0dr7ouge7eu0g8vvba26bfh