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SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes

Splicing is catalyzed by the spliceosome, a compositionally dynamic complex assembled stepwise on pre-mRNA. We reveal links between splicing machinery components and the intrinsically disordered ciliopathy protein SANS. Pathogenic mutations in SANS/USH1G lead to Usher syndrome—the most common cause...

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Detalles Bibliográficos
Autores principales:	Yildirim, Adem, Mozaffari-Jovin, Sina, Wallisch, Ann-Kathrin, Schäfer, Jessica, Ludwig, Sebastian E J, Urlaub, Henning, Lührmann, Reinhard, Wolfrum, Uwe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191790/ https://www.ncbi.nlm.nih.gov/pubmed/34023904 http://dx.doi.org/10.1093/nar/gkab386

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