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P2RX7 gene variation mediates the effect of childhood adversity and recent stress on the severity of depressive symptoms
The P2X purinoceptor 7 (P2RX7) mediates inflammatory microglial responses and is implicated in neuroimmune mechanisms of depression and neurodegenerative disorders. A number of studies suggest that psychosocial stress may precipitate depression through immune activation. Genetic association studies...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191953/ https://www.ncbi.nlm.nih.gov/pubmed/34111150 http://dx.doi.org/10.1371/journal.pone.0252766 |