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New perspectives on angiotensin-converting enzyme 2 and its related diseases

Since the worldwide outbreak of coronavirus disease 2019, angiotensin-converting enzyme 2 (ACE2) has received widespread attention as the cell receptor of the severe acute respiratory syndrome coronavirus 2 virus. At the same time, as a key enzyme in the renin-angiotensin-system, ACE2 is considered...

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Autores principales: Liu, Li-Ping, Zhang, Xiao-Li, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192247/
https://www.ncbi.nlm.nih.gov/pubmed/34168732
http://dx.doi.org/10.4239/wjd.v12.i6.839
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author Liu, Li-Ping
Zhang, Xiao-Li
Li, Jian
author_facet Liu, Li-Ping
Zhang, Xiao-Li
Li, Jian
author_sort Liu, Li-Ping
collection PubMed
description Since the worldwide outbreak of coronavirus disease 2019, angiotensin-converting enzyme 2 (ACE2) has received widespread attention as the cell receptor of the severe acute respiratory syndrome coronavirus 2 virus. At the same time, as a key enzyme in the renin-angiotensin-system, ACE2 is considered to be an endogenous negative regulator of vasoconstriction, proliferation, fibrosis, and proinflammation caused by the ACE-angiotensin II-angiotensin type 1 receptor axis. ACE2 is now implicated as being closely connected to diabetes, cardiovascular, kidney, and lung diseases, and so on. This review covers the available information on the host factors regulating ACE2 and discusses its role in a variety of pathophysiological conditions in animal models and humans.
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spelling pubmed-81922472021-06-23 New perspectives on angiotensin-converting enzyme 2 and its related diseases Liu, Li-Ping Zhang, Xiao-Li Li, Jian World J Diabetes Minireviews Since the worldwide outbreak of coronavirus disease 2019, angiotensin-converting enzyme 2 (ACE2) has received widespread attention as the cell receptor of the severe acute respiratory syndrome coronavirus 2 virus. At the same time, as a key enzyme in the renin-angiotensin-system, ACE2 is considered to be an endogenous negative regulator of vasoconstriction, proliferation, fibrosis, and proinflammation caused by the ACE-angiotensin II-angiotensin type 1 receptor axis. ACE2 is now implicated as being closely connected to diabetes, cardiovascular, kidney, and lung diseases, and so on. This review covers the available information on the host factors regulating ACE2 and discusses its role in a variety of pathophysiological conditions in animal models and humans. Baishideng Publishing Group Inc 2021-06-15 2021-06-15 /pmc/articles/PMC8192247/ /pubmed/34168732 http://dx.doi.org/10.4239/wjd.v12.i6.839 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Liu, Li-Ping
Zhang, Xiao-Li
Li, Jian
New perspectives on angiotensin-converting enzyme 2 and its related diseases
title New perspectives on angiotensin-converting enzyme 2 and its related diseases
title_full New perspectives on angiotensin-converting enzyme 2 and its related diseases
title_fullStr New perspectives on angiotensin-converting enzyme 2 and its related diseases
title_full_unstemmed New perspectives on angiotensin-converting enzyme 2 and its related diseases
title_short New perspectives on angiotensin-converting enzyme 2 and its related diseases
title_sort new perspectives on angiotensin-converting enzyme 2 and its related diseases
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192247/
https://www.ncbi.nlm.nih.gov/pubmed/34168732
http://dx.doi.org/10.4239/wjd.v12.i6.839
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