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Triglyceride regulate ACE2 level through MTHFD1

Obesity has been followed with interest as a risk factor for COVID-19, with triglycerides as one of four common criteria used to define obesity, which have been used to study the mechanism of obesity. In this study, we showed that angiotensin-converting enzyme-2 (ACE2) is widely expressed in the mou...

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Autores principales: Ma, Xiaohua, Li, Xiaojing, Wan, Bo, Miao, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192271/
https://www.ncbi.nlm.nih.gov/pubmed/34168100
http://dx.doi.org/10.1007/s12038-021-00178-y
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author Ma, Xiaohua
Li, Xiaojing
Wan, Bo
Miao, Zhigang
author_facet Ma, Xiaohua
Li, Xiaojing
Wan, Bo
Miao, Zhigang
author_sort Ma, Xiaohua
collection PubMed
description Obesity has been followed with interest as a risk factor for COVID-19, with triglycerides as one of four common criteria used to define obesity, which have been used to study the mechanism of obesity. In this study, we showed that angiotensin-converting enzyme-2 (ACE2) is widely expressed in the mouse body, including the kidney, spleen, brain, heart, lung, liver, and testis, and that ACE2 levels increased after a high-fat diet. The ACE2 levels were recorded at 0 days, 3 days, 7 days, and 14 days after a high-fat diet, and they increased at 14 days after high-fat diet initiation. In addition, triglyceride levels were also significantly increased at 14 days after high-fat diet initiation, but body weight was not changed. Furthermore, we examined the ACE2 levels in Calu3 cells (a lung cancer cell line) after triglyceride treatment, and the results indicated that ACE2 levels were increased at 25 μM and reached their peak at 200 μM. Finally, we found that the mRNA level of mthfd1 was significantly increased in the high-fat diet group. Given these findings, we hypothesize that triglycerides can regulate the expression of ACE2 and Mthfd1.
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spelling pubmed-81922712021-06-11 Triglyceride regulate ACE2 level through MTHFD1 Ma, Xiaohua Li, Xiaojing Wan, Bo Miao, Zhigang J Biosci Article Obesity has been followed with interest as a risk factor for COVID-19, with triglycerides as one of four common criteria used to define obesity, which have been used to study the mechanism of obesity. In this study, we showed that angiotensin-converting enzyme-2 (ACE2) is widely expressed in the mouse body, including the kidney, spleen, brain, heart, lung, liver, and testis, and that ACE2 levels increased after a high-fat diet. The ACE2 levels were recorded at 0 days, 3 days, 7 days, and 14 days after a high-fat diet, and they increased at 14 days after high-fat diet initiation. In addition, triglyceride levels were also significantly increased at 14 days after high-fat diet initiation, but body weight was not changed. Furthermore, we examined the ACE2 levels in Calu3 cells (a lung cancer cell line) after triglyceride treatment, and the results indicated that ACE2 levels were increased at 25 μM and reached their peak at 200 μM. Finally, we found that the mRNA level of mthfd1 was significantly increased in the high-fat diet group. Given these findings, we hypothesize that triglycerides can regulate the expression of ACE2 and Mthfd1. Springer India 2021-06-11 2021 /pmc/articles/PMC8192271/ /pubmed/34168100 http://dx.doi.org/10.1007/s12038-021-00178-y Text en © Indian Academy of Sciences 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Ma, Xiaohua
Li, Xiaojing
Wan, Bo
Miao, Zhigang
Triglyceride regulate ACE2 level through MTHFD1
title Triglyceride regulate ACE2 level through MTHFD1
title_full Triglyceride regulate ACE2 level through MTHFD1
title_fullStr Triglyceride regulate ACE2 level through MTHFD1
title_full_unstemmed Triglyceride regulate ACE2 level through MTHFD1
title_short Triglyceride regulate ACE2 level through MTHFD1
title_sort triglyceride regulate ace2 level through mthfd1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192271/
https://www.ncbi.nlm.nih.gov/pubmed/34168100
http://dx.doi.org/10.1007/s12038-021-00178-y
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