Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health worldwide. In addition to respiratory symptoms, COVID-19 is usually accompanied by systemic inflammation and liver damage in moderate and severe...

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Autores principales: Zhu, Dan-Dan, Tan, Xue-Mei, Lu, Li-Qing, Yu, Si-Jia, Jian, Ru-Li, Liang, Xin-Fang, Liao, Yi-Xuan, Fan, Wei, Barbier-Torres, Lucíia, Yang, Austin, Yang, He-Ping, Liu, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192291/
https://www.ncbi.nlm.nih.gov/pubmed/34168400
http://dx.doi.org/10.3748/wjg.v27.i22.2944
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author Zhu, Dan-Dan
Tan, Xue-Mei
Lu, Li-Qing
Yu, Si-Jia
Jian, Ru-Li
Liang, Xin-Fang
Liao, Yi-Xuan
Fan, Wei
Barbier-Torres, Lucíia
Yang, Austin
Yang, He-Ping
Liu, Ting
author_facet Zhu, Dan-Dan
Tan, Xue-Mei
Lu, Li-Qing
Yu, Si-Jia
Jian, Ru-Li
Liang, Xin-Fang
Liao, Yi-Xuan
Fan, Wei
Barbier-Torres, Lucíia
Yang, Austin
Yang, He-Ping
Liu, Ting
author_sort Zhu, Dan-Dan
collection PubMed
description Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health worldwide. In addition to respiratory symptoms, COVID-19 is usually accompanied by systemic inflammation and liver damage in moderate and severe cases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the expression of antioxidant proteins, participating in COVID-19-mediated inflammation and liver injury. Here, we show the novel reciprocal regulation between NRF2 and inflammatory mediators associated with COVID-19-related liver injury. Additionally, we describe some mechanisms and treatment strategies.
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spelling pubmed-81922912021-06-23 Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury Zhu, Dan-Dan Tan, Xue-Mei Lu, Li-Qing Yu, Si-Jia Jian, Ru-Li Liang, Xin-Fang Liao, Yi-Xuan Fan, Wei Barbier-Torres, Lucíia Yang, Austin Yang, He-Ping Liu, Ting World J Gastroenterol Review Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health worldwide. In addition to respiratory symptoms, COVID-19 is usually accompanied by systemic inflammation and liver damage in moderate and severe cases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the expression of antioxidant proteins, participating in COVID-19-mediated inflammation and liver injury. Here, we show the novel reciprocal regulation between NRF2 and inflammatory mediators associated with COVID-19-related liver injury. Additionally, we describe some mechanisms and treatment strategies. Baishideng Publishing Group Inc 2021-06-14 2021-06-14 /pmc/articles/PMC8192291/ /pubmed/34168400 http://dx.doi.org/10.3748/wjg.v27.i22.2944 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Zhu, Dan-Dan
Tan, Xue-Mei
Lu, Li-Qing
Yu, Si-Jia
Jian, Ru-Li
Liang, Xin-Fang
Liao, Yi-Xuan
Fan, Wei
Barbier-Torres, Lucíia
Yang, Austin
Yang, He-Ping
Liu, Ting
Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury
title Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury
title_full Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury
title_fullStr Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury
title_full_unstemmed Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury
title_short Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury
title_sort interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in covid-19-related liver injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192291/
https://www.ncbi.nlm.nih.gov/pubmed/34168400
http://dx.doi.org/10.3748/wjg.v27.i22.2944
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