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A clinical evaluation of VO(2) kinetics in kidney transplant recipients

PURPOSE: Aerobic exercise capacity is reduced in patients with chronic kidney disease, partly due to alterations at the muscular and microvascular level. This study evaluated oxygen uptake (VO(2)) kinetics as indicator of muscular oxidative metabolism in a population of Kidney Transplant Recipients...

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Autores principales: Patti, Alessandro, Neunhaeuserer, Daniel, Ortolan, Sara, Roman, Fausto, Gasperetti, Andrea, Battista, Francesca, Di Bella, Caterina, Gobbo, Stefano, Bergamin, Marco, Furian, Lucrezia, Ermolao, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192378/
https://www.ncbi.nlm.nih.gov/pubmed/33811560
http://dx.doi.org/10.1007/s00421-021-04672-x
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author Patti, Alessandro
Neunhaeuserer, Daniel
Ortolan, Sara
Roman, Fausto
Gasperetti, Andrea
Battista, Francesca
Di Bella, Caterina
Gobbo, Stefano
Bergamin, Marco
Furian, Lucrezia
Ermolao, Andrea
author_facet Patti, Alessandro
Neunhaeuserer, Daniel
Ortolan, Sara
Roman, Fausto
Gasperetti, Andrea
Battista, Francesca
Di Bella, Caterina
Gobbo, Stefano
Bergamin, Marco
Furian, Lucrezia
Ermolao, Andrea
author_sort Patti, Alessandro
collection PubMed
description PURPOSE: Aerobic exercise capacity is reduced in patients with chronic kidney disease, partly due to alterations at the muscular and microvascular level. This study evaluated oxygen uptake (VO(2)) kinetics as indicator of muscular oxidative metabolism in a population of Kidney Transplant Recipients (KTRs). METHODS: Two groups of KTRs enrolled 3 (n = 21) and 12 months (n = 14) after transplantation and a control group of healthy young adults (n = 16) underwent cardiopulmonary exercise testing on cycle-ergometer. The protocol consisted in two subsequent constant, moderate-load exercise phases with a final incremental test until exhaustion. RESULTS: The time constant of VO(2) kinetics was slower in KTRs at 3 and 12 months after transplantation compared to controls (50.4 ± 13.1 s and 43.8 ± 11.6 s vs 28.9 ± 8.4 s, respectively; P < 0.01). Peak VO(2) was lower in KTRs evaluated 3 months after transplantation compared to patients evaluated after 1 year (21.3 ± 4.3 and 26.4 ± 8.0 mL/kg/min; P = 0.04). Blood haemoglobin (Hb) concentration was higher in KTRs evaluated at 12 months (12.8 ± 1.7 vs 14.6 ± 1.7 g/dL; P < 0.01). Among KTRs, τ showed a moderate negative correlation with Peak VO(2) (ρ = − 0.52) and Oxygen uptake efficiency slope (OUES) (r = − 0.57) while no significant correlation with Hb and peak heart rate. CONCLUSIONS: KTRs show slower VO(2) kinetics compared to healthy controls. Hb and peak VO(2) seem to improve during the first year after transplantation. VO(2) kinetics were significantly associated with indices of cardiorespiratory fitness, but less with central determinants of aerobic capacity, thus suggesting a potential usefulness of adding this index of muscular oxidative metabolism to functional evaluation in KTRs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00421-021-04672-x.
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spelling pubmed-81923782021-06-28 A clinical evaluation of VO(2) kinetics in kidney transplant recipients Patti, Alessandro Neunhaeuserer, Daniel Ortolan, Sara Roman, Fausto Gasperetti, Andrea Battista, Francesca Di Bella, Caterina Gobbo, Stefano Bergamin, Marco Furian, Lucrezia Ermolao, Andrea Eur J Appl Physiol Original Article PURPOSE: Aerobic exercise capacity is reduced in patients with chronic kidney disease, partly due to alterations at the muscular and microvascular level. This study evaluated oxygen uptake (VO(2)) kinetics as indicator of muscular oxidative metabolism in a population of Kidney Transplant Recipients (KTRs). METHODS: Two groups of KTRs enrolled 3 (n = 21) and 12 months (n = 14) after transplantation and a control group of healthy young adults (n = 16) underwent cardiopulmonary exercise testing on cycle-ergometer. The protocol consisted in two subsequent constant, moderate-load exercise phases with a final incremental test until exhaustion. RESULTS: The time constant of VO(2) kinetics was slower in KTRs at 3 and 12 months after transplantation compared to controls (50.4 ± 13.1 s and 43.8 ± 11.6 s vs 28.9 ± 8.4 s, respectively; P < 0.01). Peak VO(2) was lower in KTRs evaluated 3 months after transplantation compared to patients evaluated after 1 year (21.3 ± 4.3 and 26.4 ± 8.0 mL/kg/min; P = 0.04). Blood haemoglobin (Hb) concentration was higher in KTRs evaluated at 12 months (12.8 ± 1.7 vs 14.6 ± 1.7 g/dL; P < 0.01). Among KTRs, τ showed a moderate negative correlation with Peak VO(2) (ρ = − 0.52) and Oxygen uptake efficiency slope (OUES) (r = − 0.57) while no significant correlation with Hb and peak heart rate. CONCLUSIONS: KTRs show slower VO(2) kinetics compared to healthy controls. Hb and peak VO(2) seem to improve during the first year after transplantation. VO(2) kinetics were significantly associated with indices of cardiorespiratory fitness, but less with central determinants of aerobic capacity, thus suggesting a potential usefulness of adding this index of muscular oxidative metabolism to functional evaluation in KTRs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00421-021-04672-x. Springer Berlin Heidelberg 2021-04-03 2021 /pmc/articles/PMC8192378/ /pubmed/33811560 http://dx.doi.org/10.1007/s00421-021-04672-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Patti, Alessandro
Neunhaeuserer, Daniel
Ortolan, Sara
Roman, Fausto
Gasperetti, Andrea
Battista, Francesca
Di Bella, Caterina
Gobbo, Stefano
Bergamin, Marco
Furian, Lucrezia
Ermolao, Andrea
A clinical evaluation of VO(2) kinetics in kidney transplant recipients
title A clinical evaluation of VO(2) kinetics in kidney transplant recipients
title_full A clinical evaluation of VO(2) kinetics in kidney transplant recipients
title_fullStr A clinical evaluation of VO(2) kinetics in kidney transplant recipients
title_full_unstemmed A clinical evaluation of VO(2) kinetics in kidney transplant recipients
title_short A clinical evaluation of VO(2) kinetics in kidney transplant recipients
title_sort clinical evaluation of vo(2) kinetics in kidney transplant recipients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192378/
https://www.ncbi.nlm.nih.gov/pubmed/33811560
http://dx.doi.org/10.1007/s00421-021-04672-x
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