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Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men

PURPOSE: The present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines and growth factors. A secondary aim was to investigate whether a novel sprint interval training (SIT) intervention (3 × 20 s ‘all out’ static sprints, twice a week for 8 weeks) would...

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Autores principales: Yasar, Zerbu, Elliott, Bradley T., Kyriakidou, Yvoni, Nwokoma, Chiazor T., Postlethwaite, Ruth D., Gaffney, Christopher J., Dewhurst, Susan, Hayes, Lawrence D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192388/
https://www.ncbi.nlm.nih.gov/pubmed/33723630
http://dx.doi.org/10.1007/s00421-021-04635-2
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author Yasar, Zerbu
Elliott, Bradley T.
Kyriakidou, Yvoni
Nwokoma, Chiazor T.
Postlethwaite, Ruth D.
Gaffney, Christopher J.
Dewhurst, Susan
Hayes, Lawrence D.
author_facet Yasar, Zerbu
Elliott, Bradley T.
Kyriakidou, Yvoni
Nwokoma, Chiazor T.
Postlethwaite, Ruth D.
Gaffney, Christopher J.
Dewhurst, Susan
Hayes, Lawrence D.
author_sort Yasar, Zerbu
collection PubMed
description PURPOSE: The present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines and growth factors. A secondary aim was to investigate whether a novel sprint interval training (SIT) intervention (3 × 20 s ‘all out’ static sprints, twice a week for 8 weeks) would affect inflammatory markers in older men. METHODS: Nine older men [68 (1) years] and eleven younger men [28 (2) years] comprised the younger group. Aerobic fitness and inflammatory markers were taken at baseline for both groups and following the SIT intervention for the older group. RESULTS: Interleukin (IL)-8, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) were unchanged for the older and younger groups at baseline (IL-8, p = 0.819; MCP-1, p = 0.248; VEGF, p = 0.264). Epidermal growth factor (EGF) was greater in the older group compared to the younger group at baseline [142 (20) pg mL(−1) and 60 (12) pg mL(−1), respectively, p = 0.001, Cohen's d = 1.64]. Following SIT, older men decreased EGF to 100 (12) pg mL(−1) which was similar to that of young men who did not undergo training (p = 0.113, Cohen's d = 1.07). CONCLUSION: Older aerobically trained men have greater serum EGF than younger aerobically trained men. A novel SIT intervention in older men can shift circulating EGF towards trained younger concentrations. As lower EGF has previously been associated with longevity in C. elegans, the manipulative effect of SIT on EGF in healthy ageing in the human may be of further interest.
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spelling pubmed-81923882021-06-28 Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men Yasar, Zerbu Elliott, Bradley T. Kyriakidou, Yvoni Nwokoma, Chiazor T. Postlethwaite, Ruth D. Gaffney, Christopher J. Dewhurst, Susan Hayes, Lawrence D. Eur J Appl Physiol Original Article PURPOSE: The present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines and growth factors. A secondary aim was to investigate whether a novel sprint interval training (SIT) intervention (3 × 20 s ‘all out’ static sprints, twice a week for 8 weeks) would affect inflammatory markers in older men. METHODS: Nine older men [68 (1) years] and eleven younger men [28 (2) years] comprised the younger group. Aerobic fitness and inflammatory markers were taken at baseline for both groups and following the SIT intervention for the older group. RESULTS: Interleukin (IL)-8, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) were unchanged for the older and younger groups at baseline (IL-8, p = 0.819; MCP-1, p = 0.248; VEGF, p = 0.264). Epidermal growth factor (EGF) was greater in the older group compared to the younger group at baseline [142 (20) pg mL(−1) and 60 (12) pg mL(−1), respectively, p = 0.001, Cohen's d = 1.64]. Following SIT, older men decreased EGF to 100 (12) pg mL(−1) which was similar to that of young men who did not undergo training (p = 0.113, Cohen's d = 1.07). CONCLUSION: Older aerobically trained men have greater serum EGF than younger aerobically trained men. A novel SIT intervention in older men can shift circulating EGF towards trained younger concentrations. As lower EGF has previously been associated with longevity in C. elegans, the manipulative effect of SIT on EGF in healthy ageing in the human may be of further interest. Springer Berlin Heidelberg 2021-03-16 2021 /pmc/articles/PMC8192388/ /pubmed/33723630 http://dx.doi.org/10.1007/s00421-021-04635-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Yasar, Zerbu
Elliott, Bradley T.
Kyriakidou, Yvoni
Nwokoma, Chiazor T.
Postlethwaite, Ruth D.
Gaffney, Christopher J.
Dewhurst, Susan
Hayes, Lawrence D.
Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men
title Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men
title_full Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men
title_fullStr Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men
title_full_unstemmed Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men
title_short Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men
title_sort sprint interval training (sit) reduces serum epidermal growth factor (egf), but not other inflammatory cytokines in trained older men
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192388/
https://www.ncbi.nlm.nih.gov/pubmed/33723630
http://dx.doi.org/10.1007/s00421-021-04635-2
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