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Early-phase (18)F-FP-CIT and (18)F-flutemetamol PET were significantly correlated

Little is known about whether early-phase PET images of (18)F-FP-CIT match those of amyloid PET. Here, we compared early-phase (18)F-FP-CIT and (18)F-flutemetamol PET images in patients who underwent both within a 1-month interval. The SUVR on early-phase (18)F-FP-CIT PET (median, 0.86) was signific...

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Detalles Bibliográficos
Autores principales: An, Young-Sil, Yoon, Jung Han, Son, Sang Joon, Hong, Chang Hyung, Lee, Su Jin, Yoon, Joon-Kee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192502/
https://www.ncbi.nlm.nih.gov/pubmed/34112926
http://dx.doi.org/10.1038/s41598-021-91891-z
Descripción
Sumario:Little is known about whether early-phase PET images of (18)F-FP-CIT match those of amyloid PET. Here, we compared early-phase (18)F-FP-CIT and (18)F-flutemetamol PET images in patients who underwent both within a 1-month interval. The SUVR on early-phase (18)F-FP-CIT PET (median, 0.86) was significantly lower than that of (18)F-flutemetamol PET (median, 0.91, p < 0.001) for total brain regions including all cerebral lobes and central structures. This significant difference persisted for each brain region except central structures (p = 0.232). The SUVR of total brain regions obtained from early (18)F-FP-CIT PET showed a very strong correlation with that of (18)F-flutemetamol PET (rho = 0.80, p < 0.001). Among the kinetic parameters, only R1 showed a statistically significant correlation between the two techniques for all brain regions (rho = 0.89, p < 0.001). R1 from (18)F-FP-CIT (median, 0.77) was significantly lower in all areas of the brain compared to R1 from (18)F-flutemetamol PET (median, 0.81, p < 0.001).(18)F-FP-CIT demonstrated lower uptake in cortical brain regions than (18)F-flutemetamol on early-phase PET. However, both early-phase PETs demonstrated significant correlation of uptake.