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Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation

Cigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. Spirometry...

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Autores principales: Darabseh, Mohammad Z., Maden-Wilkinson, Thomas M., Welbourne, George, Wüst, Rob C. I., Ahmed, Nessar, Aushah, Hakima, Selfe, James, Morse, Christopher I., Degens, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192509/
https://www.ncbi.nlm.nih.gov/pubmed/34112815
http://dx.doi.org/10.1038/s41598-021-91510-x
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author Darabseh, Mohammad Z.
Maden-Wilkinson, Thomas M.
Welbourne, George
Wüst, Rob C. I.
Ahmed, Nessar
Aushah, Hakima
Selfe, James
Morse, Christopher I.
Degens, Hans
author_facet Darabseh, Mohammad Z.
Maden-Wilkinson, Thomas M.
Welbourne, George
Wüst, Rob C. I.
Ahmed, Nessar
Aushah, Hakima
Selfe, James
Morse, Christopher I.
Degens, Hans
author_sort Darabseh, Mohammad Z.
collection PubMed
description Cigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. Spirometry, skeletal muscle function, circulating carboxyhaemoglobin levels, advanced glycation end products (AGEs), markers of oxidative stress and serum cytokines were measured in 38 non-smokers, and in 48 cigarette smokers at baseline and after 14 days of smoking cessation. Peak expiratory flow (p = 0.004) and forced expiratory volume in 1 s/forced vital capacity (p = 0.037) were lower in smokers compared to non-smokers but did not change significantly after smoking cessation. Smoking cessation increased skeletal muscle fatigue resistance (p < 0.001). Haemoglobin content, haematocrit, carboxyhaemoglobin, total AGEs, malondialdehyde, TNF-α, IL-2, IL-4, IL-6 and IL-10 (p < 0.05) levels were higher, and total antioxidant status (TAS), IL-12p70 and eosinophil numbers were lower (p < 0.05) in smokers. IL-4, IL-6, IL-10 and IL-12p70 had returned towards levels seen in non-smokers after 14 days smoking cessation (p < 0.05), and IL-2 and TNF-α showed a similar pattern but had not yet fully returned to levels seen in non-smokers. Haemoglobin, haematocrit, eosinophil count, AGEs, MDA and TAS did not significantly change with smoking cessation. Two weeks of smoking cessation was accompanied with an improved muscle fatigue resistance and a reduction in low-grade systemic inflammation in smokers.
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spelling pubmed-81925092021-06-14 Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation Darabseh, Mohammad Z. Maden-Wilkinson, Thomas M. Welbourne, George Wüst, Rob C. I. Ahmed, Nessar Aushah, Hakima Selfe, James Morse, Christopher I. Degens, Hans Sci Rep Article Cigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. Spirometry, skeletal muscle function, circulating carboxyhaemoglobin levels, advanced glycation end products (AGEs), markers of oxidative stress and serum cytokines were measured in 38 non-smokers, and in 48 cigarette smokers at baseline and after 14 days of smoking cessation. Peak expiratory flow (p = 0.004) and forced expiratory volume in 1 s/forced vital capacity (p = 0.037) were lower in smokers compared to non-smokers but did not change significantly after smoking cessation. Smoking cessation increased skeletal muscle fatigue resistance (p < 0.001). Haemoglobin content, haematocrit, carboxyhaemoglobin, total AGEs, malondialdehyde, TNF-α, IL-2, IL-4, IL-6 and IL-10 (p < 0.05) levels were higher, and total antioxidant status (TAS), IL-12p70 and eosinophil numbers were lower (p < 0.05) in smokers. IL-4, IL-6, IL-10 and IL-12p70 had returned towards levels seen in non-smokers after 14 days smoking cessation (p < 0.05), and IL-2 and TNF-α showed a similar pattern but had not yet fully returned to levels seen in non-smokers. Haemoglobin, haematocrit, eosinophil count, AGEs, MDA and TAS did not significantly change with smoking cessation. Two weeks of smoking cessation was accompanied with an improved muscle fatigue resistance and a reduction in low-grade systemic inflammation in smokers. Nature Publishing Group UK 2021-06-10 /pmc/articles/PMC8192509/ /pubmed/34112815 http://dx.doi.org/10.1038/s41598-021-91510-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Darabseh, Mohammad Z.
Maden-Wilkinson, Thomas M.
Welbourne, George
Wüst, Rob C. I.
Ahmed, Nessar
Aushah, Hakima
Selfe, James
Morse, Christopher I.
Degens, Hans
Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
title Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
title_full Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
title_fullStr Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
title_full_unstemmed Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
title_short Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
title_sort fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192509/
https://www.ncbi.nlm.nih.gov/pubmed/34112815
http://dx.doi.org/10.1038/s41598-021-91510-x
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