Histone citrullination: a new target for tumors

As the main protein components of chromatin, histones play central roles in gene regulation as spools of winding DNA. Histones are subject to various modifications, including phosphorylation, acetylation, glycosylation, methylation, ubiquitination and citrullination, which affect gene transcription....

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Detalles Bibliográficos
Autores principales: Zhu, Dongwei, Zhang, Yue, Wang, Shengjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192683/
https://www.ncbi.nlm.nih.gov/pubmed/34116679
http://dx.doi.org/10.1186/s12943-021-01373-z
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author Zhu, Dongwei
Zhang, Yue
Wang, Shengjun
author_facet Zhu, Dongwei
Zhang, Yue
Wang, Shengjun
author_sort Zhu, Dongwei
collection PubMed
description As the main protein components of chromatin, histones play central roles in gene regulation as spools of winding DNA. Histones are subject to various modifications, including phosphorylation, acetylation, glycosylation, methylation, ubiquitination and citrullination, which affect gene transcription. Histone citrullination, a posttranscriptional modification catalyzed by peptidyl arginine deiminase (PAD) enzymes, is involved in human carcinogenesis. In this study, we highlighted the functions of histone citrullination in physiological regulation and tumors. Additionally, because histone citrullination involves forming neutrophil extracellular traps (NETs), the relationship between NETs and tumors was illustrated. Finally, the clinical application of histone citrullination and PAD inhibitors was discussed.
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spelling pubmed-81926832021-06-11 Histone citrullination: a new target for tumors Zhu, Dongwei Zhang, Yue Wang, Shengjun Mol Cancer Review As the main protein components of chromatin, histones play central roles in gene regulation as spools of winding DNA. Histones are subject to various modifications, including phosphorylation, acetylation, glycosylation, methylation, ubiquitination and citrullination, which affect gene transcription. Histone citrullination, a posttranscriptional modification catalyzed by peptidyl arginine deiminase (PAD) enzymes, is involved in human carcinogenesis. In this study, we highlighted the functions of histone citrullination in physiological regulation and tumors. Additionally, because histone citrullination involves forming neutrophil extracellular traps (NETs), the relationship between NETs and tumors was illustrated. Finally, the clinical application of histone citrullination and PAD inhibitors was discussed. BioMed Central 2021-06-11 /pmc/articles/PMC8192683/ /pubmed/34116679 http://dx.doi.org/10.1186/s12943-021-01373-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhu, Dongwei
Zhang, Yue
Wang, Shengjun
Histone citrullination: a new target for tumors
title Histone citrullination: a new target for tumors
title_full Histone citrullination: a new target for tumors
title_fullStr Histone citrullination: a new target for tumors
title_full_unstemmed Histone citrullination: a new target for tumors
title_short Histone citrullination: a new target for tumors
title_sort histone citrullination: a new target for tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192683/
https://www.ncbi.nlm.nih.gov/pubmed/34116679
http://dx.doi.org/10.1186/s12943-021-01373-z
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