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Pediatric Obesity—A Potential Risk Factor for Systemic Inflammatory Syndrome Associated to COVID-19, a Case Report

The well-documented systemic inflammation associated to pediatric obesity might act as an augmenting factor for other inflammatory conditions, such as pediatric inflammatory multisystem syndrome (PIMS) associated to COVID-19. We report the case of 9-year-old boy admitted in our clinic for fever, ano...

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Autores principales: Mărginean, Cristina Oana, Meliţ, Lorena Elena, Săsăran, Maria Oana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192702/
https://www.ncbi.nlm.nih.gov/pubmed/34123977
http://dx.doi.org/10.3389/fped.2021.681626
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author Mărginean, Cristina Oana
Meliţ, Lorena Elena
Săsăran, Maria Oana
author_facet Mărginean, Cristina Oana
Meliţ, Lorena Elena
Săsăran, Maria Oana
author_sort Mărginean, Cristina Oana
collection PubMed
description The well-documented systemic inflammation associated to pediatric obesity might act as an augmenting factor for other inflammatory conditions, such as pediatric inflammatory multisystem syndrome (PIMS) associated to COVID-19. We report the case of 9-year-old boy admitted in our clinic for fever, anorexia, and fatigability. The clinical exam revealed influenced general status, palpebral edema, non-exudative conjunctivitis, and abdominal tenderness. The patient weighed 45 kg. The laboratory tests at the time of admission pointed out anemia, lymphopenia; elevated inflammatory biomarkers, NT-proBNP, D-dimers, and troponin; high liver enzymes and lactate dehydrogenase levels, as well as hypoalbuminemia. The patient tested positive for both RT-PCR and serology for SARS-CoV-2 infection. We initiated intravenous immunoglobulin and methylprednisolone, associated with empirical antibiotic, anticoagulation therapy, and symptomatic treatment. The patient was discharged on the 7th day of admission with the recommendation to continue enoxaparin and methylprednisolone at home tapering the dose for the next week. The subclinical inflammatory status associated to obesity might serve as an unfortunate trigger factor for the development of COVID-19 severe forms in children. Therefore, clinicians should be aware that children with obesity and COVID-19 represent a peculiar group that should be closely monitored and thoroughly assessed in order to preempt life-threatening complications, such as PIMS.
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spelling pubmed-81927022021-06-12 Pediatric Obesity—A Potential Risk Factor for Systemic Inflammatory Syndrome Associated to COVID-19, a Case Report Mărginean, Cristina Oana Meliţ, Lorena Elena Săsăran, Maria Oana Front Pediatr Pediatrics The well-documented systemic inflammation associated to pediatric obesity might act as an augmenting factor for other inflammatory conditions, such as pediatric inflammatory multisystem syndrome (PIMS) associated to COVID-19. We report the case of 9-year-old boy admitted in our clinic for fever, anorexia, and fatigability. The clinical exam revealed influenced general status, palpebral edema, non-exudative conjunctivitis, and abdominal tenderness. The patient weighed 45 kg. The laboratory tests at the time of admission pointed out anemia, lymphopenia; elevated inflammatory biomarkers, NT-proBNP, D-dimers, and troponin; high liver enzymes and lactate dehydrogenase levels, as well as hypoalbuminemia. The patient tested positive for both RT-PCR and serology for SARS-CoV-2 infection. We initiated intravenous immunoglobulin and methylprednisolone, associated with empirical antibiotic, anticoagulation therapy, and symptomatic treatment. The patient was discharged on the 7th day of admission with the recommendation to continue enoxaparin and methylprednisolone at home tapering the dose for the next week. The subclinical inflammatory status associated to obesity might serve as an unfortunate trigger factor for the development of COVID-19 severe forms in children. Therefore, clinicians should be aware that children with obesity and COVID-19 represent a peculiar group that should be closely monitored and thoroughly assessed in order to preempt life-threatening complications, such as PIMS. Frontiers Media S.A. 2021-05-28 /pmc/articles/PMC8192702/ /pubmed/34123977 http://dx.doi.org/10.3389/fped.2021.681626 Text en Copyright © 2021 Mărginean, Meliţ and Săsăran. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Mărginean, Cristina Oana
Meliţ, Lorena Elena
Săsăran, Maria Oana
Pediatric Obesity—A Potential Risk Factor for Systemic Inflammatory Syndrome Associated to COVID-19, a Case Report
title Pediatric Obesity—A Potential Risk Factor for Systemic Inflammatory Syndrome Associated to COVID-19, a Case Report
title_full Pediatric Obesity—A Potential Risk Factor for Systemic Inflammatory Syndrome Associated to COVID-19, a Case Report
title_fullStr Pediatric Obesity—A Potential Risk Factor for Systemic Inflammatory Syndrome Associated to COVID-19, a Case Report
title_full_unstemmed Pediatric Obesity—A Potential Risk Factor for Systemic Inflammatory Syndrome Associated to COVID-19, a Case Report
title_short Pediatric Obesity—A Potential Risk Factor for Systemic Inflammatory Syndrome Associated to COVID-19, a Case Report
title_sort pediatric obesity—a potential risk factor for systemic inflammatory syndrome associated to covid-19, a case report
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192702/
https://www.ncbi.nlm.nih.gov/pubmed/34123977
http://dx.doi.org/10.3389/fped.2021.681626
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