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ECMO Rescues Patients With Acute Respiratory Failure Related to GPA

Granulomatosis with polyangiitis (GPA) is a subtype of anti-neutrophil cytoplasmic antibody-associated vasculitis with a wide range of clinical symptoms related to the systemic involvement of small blood vessels. The respiratory system is one of the most frequently involved, and life-threatening acu...

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Autores principales: Wan, Rongjun, Yang, Wenzhe, Ma, Xinhua, Yang, Wei, Pan, Pinhua, Hu, Chengping, Chen, Qiong, Zhou, Yaou, Lu, Rongli, Fang, Yimin, Li, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192709/
https://www.ncbi.nlm.nih.gov/pubmed/34124098
http://dx.doi.org/10.3389/fmed.2021.671396
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author Wan, Rongjun
Yang, Wenzhe
Ma, Xinhua
Yang, Wei
Pan, Pinhua
Hu, Chengping
Chen, Qiong
Zhou, Yaou
Lu, Rongli
Fang, Yimin
Li, Yuanyuan
author_facet Wan, Rongjun
Yang, Wenzhe
Ma, Xinhua
Yang, Wei
Pan, Pinhua
Hu, Chengping
Chen, Qiong
Zhou, Yaou
Lu, Rongli
Fang, Yimin
Li, Yuanyuan
author_sort Wan, Rongjun
collection PubMed
description Granulomatosis with polyangiitis (GPA) is a subtype of anti-neutrophil cytoplasmic antibody-associated vasculitis with a wide range of clinical symptoms related to the systemic involvement of small blood vessels. The respiratory system is one of the most frequently involved, and life-threatening acute respiratory failure could occur due to diffusive alveolar hemorrhage and tracheal stenosis. When maximum mechanical ventilation is unable to maintain oxygenation, extracorporeal membrane oxygenation (ECMO) should be considered as the final respiratory supportive method, if available. Here we present a 32-year-old male patient with acute respiratory failure (ARF) related to GPA, who was rescued by winning time for accurate diagnosis and appropriate treatment. Additionally, we reviewed more than 60 GPA-related ARF cases on multiple online databases, summarized the clinical manifestations of these patients, and concluded that ECMO plays an important role in further respiratory support for ARF patients with GPA and assists in accurate and timely diagnosis and appropriate treatment, thus helping them recuperate.
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spelling pubmed-81927092021-06-12 ECMO Rescues Patients With Acute Respiratory Failure Related to GPA Wan, Rongjun Yang, Wenzhe Ma, Xinhua Yang, Wei Pan, Pinhua Hu, Chengping Chen, Qiong Zhou, Yaou Lu, Rongli Fang, Yimin Li, Yuanyuan Front Med (Lausanne) Medicine Granulomatosis with polyangiitis (GPA) is a subtype of anti-neutrophil cytoplasmic antibody-associated vasculitis with a wide range of clinical symptoms related to the systemic involvement of small blood vessels. The respiratory system is one of the most frequently involved, and life-threatening acute respiratory failure could occur due to diffusive alveolar hemorrhage and tracheal stenosis. When maximum mechanical ventilation is unable to maintain oxygenation, extracorporeal membrane oxygenation (ECMO) should be considered as the final respiratory supportive method, if available. Here we present a 32-year-old male patient with acute respiratory failure (ARF) related to GPA, who was rescued by winning time for accurate diagnosis and appropriate treatment. Additionally, we reviewed more than 60 GPA-related ARF cases on multiple online databases, summarized the clinical manifestations of these patients, and concluded that ECMO plays an important role in further respiratory support for ARF patients with GPA and assists in accurate and timely diagnosis and appropriate treatment, thus helping them recuperate. Frontiers Media S.A. 2021-05-28 /pmc/articles/PMC8192709/ /pubmed/34124098 http://dx.doi.org/10.3389/fmed.2021.671396 Text en Copyright © 2021 Wan, Yang, Ma, Yang, Pan, Hu, Chen, Zhou, Lu, Fang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Wan, Rongjun
Yang, Wenzhe
Ma, Xinhua
Yang, Wei
Pan, Pinhua
Hu, Chengping
Chen, Qiong
Zhou, Yaou
Lu, Rongli
Fang, Yimin
Li, Yuanyuan
ECMO Rescues Patients With Acute Respiratory Failure Related to GPA
title ECMO Rescues Patients With Acute Respiratory Failure Related to GPA
title_full ECMO Rescues Patients With Acute Respiratory Failure Related to GPA
title_fullStr ECMO Rescues Patients With Acute Respiratory Failure Related to GPA
title_full_unstemmed ECMO Rescues Patients With Acute Respiratory Failure Related to GPA
title_short ECMO Rescues Patients With Acute Respiratory Failure Related to GPA
title_sort ecmo rescues patients with acute respiratory failure related to gpa
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192709/
https://www.ncbi.nlm.nih.gov/pubmed/34124098
http://dx.doi.org/10.3389/fmed.2021.671396
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