Heparanase inhibition preserves the endothelial glycocalyx in lung grafts and improves lung preservation and transplant outcomes

The endothelial glycocalyx (eGC) is considered a key regulator of several mechanisms that prevent vascular injury and disease. Degradation of this macromolecular layer may be associated with post-transplant graft dysfunction. In this study, we aimed to demonstrate the benefits of eGC protection via...

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Detalles Bibliográficos
Autores principales: Noda, Kentaro, Philips, Brian J., Snyder, Mark E., Phillippi, Julie A., Sullivan, Mara, Stolz, Donna B., Ren, Xi, Luketich, James D., Sanchez, Pablo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192744/
https://www.ncbi.nlm.nih.gov/pubmed/34112915
http://dx.doi.org/10.1038/s41598-021-91777-0

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