Cargando…

I(nsp1)ecting SARS-CoV-2–ribosome interactions

While SARS-CoV-2 is causing modern human history’s most serious health crisis and upending our way of life, clinical and basic research on the virus is advancing rapidly, leading to fascinating discoveries. Two studies have revealed how the viral virulence factor, nonstructural protein 1 (Nsp1), bin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simeoni, Matthieu, Cavinato, Théo, Rodriguez, Daniel, Gatfield, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192748/ https://www.ncbi.nlm.nih.gov/pubmed/34112887 http://dx.doi.org/10.1038/s42003-021-02265-0

Ejemplares similares

SARS-CoV-2 NSP1 induces mRNA cleavages on the ribosome
por: Tardivat, Yann, et al.
Publicado: (2023)

SARS-CoV-2 Nsp1 mediated mRNA degradation requires mRNA interaction with the ribosome
por: Shehata, Soraya I., et al.
Publicado: (2023)

A Computational Study on the Interaction of NSP10 and NSP14: Unraveling the RNA Synthesis Proofreading Mechanism in SARS-CoV-2, SARS-CoV, and MERS-CoV
por: Sarma, Himakshi, et al.
Publicado: (2022)

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
por: Kirchdoerfer, Robert N., et al.
Publicado: (2019)

Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2–encoded Nsp1
por: Wang, Xingjun, et al.
Publicado: (2022)

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase
por: Benoni, Roberto, et al.
Publicado: (2021)

Scalable Inhibitors of the Nsp3–Nsp4 Coupling in SARS-CoV-2
por: Azizogli, Abdul-Rahman, et al.
Publicado: (2023)

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2
por: Afsar, Mohammad, et al.
Publicado: (2022)

Author Correction: SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation
por: Schubert, Katharina, et al.
Publicado: (2020)

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity
por: Czarna, Anna, et al.
Publicado: (2022)

Nsp3-N interactions are critical for SARS-CoV-2 fitness and virulence
por: Li, Pengfei, et al.
Publicado: (2023)

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
por: Yuen, Chun-Kit, et al.
Publicado: (2020)

NMR assignment of the SARS-CoV protein nsp1
por: Almeida, M. S., et al.
Publicado: (2006)

Identification of novel mutations in the methyltransferase complex (Nsp10-Nsp16) of SARS-CoV-2
por: Azad, Gajendra Kumar
Publicado: (2020)

Insights into SARS-CoV transcription and replication from the structure of the nsp7–nsp8 hexadecamer
por: Zhai, Yujia, et al.
Publicado: (2005)

Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling Pathway
por: Naik, Nenavath Gopal, et al.
Publicado: (2022)

Superantigens and SARS-CoV-2
por: Hamdy, Adam, et al.
Publicado: (2022)

Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation
por: Lapointe, Christopher P., et al.
Publicado: (2021)

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2
por: Peng, Qi, et al.
Publicado: (2020)

Selenoprotein S Interacts with the Replication and Transcription Complex of SARS-CoV-2 by Binding nsp7
por: Ghelichkhani, Farid, et al.
Publicado: (2023)

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine
por: Rosas-Lemus, Monica, et al.
Publicado: (2020)

Molecular cloning, expression, and purification of SARS-CoV nsp13
por: Fan, Zheng, et al.
Publicado: (2005)

Parsing the role of NSP1 in SARS-CoV-2 infection
por: Fisher, Tal, et al.
Publicado: (2022)

Parsing the role of NSP1 in SARS-CoV-2 infection
por: Fisher, Tal, et al.
Publicado: (2022)

Mutations in SARS-CoV-2 variant nsp6 enhance type-I interferon antagonism
por: Bills, Cody J., et al.
Publicado: (2023)

Protein-protein interaction of RdRp with its co-factor NSP8 and NSP7 to decipher the interface hotspot residues for drug targeting: A comparison between SARS-CoV-2 and SARS-CoV
por: Sarma, Himakshi, et al.
Publicado: (2022)

Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16
por: Kozielski, Frank, et al.
Publicado: (2021)

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase
por: Newman, Joseph A., et al.
Publicado: (2021)

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein
por: Walter, Marius, et al.
Publicado: (2022)

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein
por: Walter, Marius, et al.
Publicado: (2022)

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics
por: Courouble, Valentine V., et al.
Publicado: (2021)

Activation of the SARS-CoV-2 NSP14 3′–5′ exoribonuclease by NSP10 and response to antiviral inhibitors
por: Riccio, Amanda A., et al.
Publicado: (2021)

Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening
por: Bobrovs, Raitis, et al.
Publicado: (2021)

SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle
por: Zimmermann, Liv, et al.
Publicado: (2023)

Equitable distribution of SARS-CoV-2 tests
por: Garcia-Bereguiain, Miguel Angel, et al.
Publicado: (2022)

SARS-CoV-2 and Arthropods: A Review
por: Higgs, Stephen, et al.
Publicado: (2022)

SARS-CoV-2 S Glycoprotein Stabilization Strategies
por: Pedenko, Borys, et al.
Publicado: (2023)

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome
por: Bhatt, Pramod R., et al.
Publicado: (2021)

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2
por: Ogando, Natacha S., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_56hbip15fhdgp3q5r8303da2rh