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Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients
Radiotherapy-related caries is a complication of radiotherapy for nasopharyngeal carcinoma; however, factors influencing the occurrence, accurate prediction of onset, and protective factors of radiotherapy-related caries remain unclear. This study analyzed risk factors, disease predictors, and prote...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192759/ https://www.ncbi.nlm.nih.gov/pubmed/34112869 http://dx.doi.org/10.1038/s41598-021-91600-w |
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author | Li, Zheng Wu, Qiuji Meng, Xiangyu Yu, Haijun Jiang, Dazhen Chen, Gaili Hu, Xiaoyan Hua, Xinying Wang, Xiaoyong Wang, Dajiang Zhao, Hongli Zhong, Yahua |
author_facet | Li, Zheng Wu, Qiuji Meng, Xiangyu Yu, Haijun Jiang, Dazhen Chen, Gaili Hu, Xiaoyan Hua, Xinying Wang, Xiaoyong Wang, Dajiang Zhao, Hongli Zhong, Yahua |
author_sort | Li, Zheng |
collection | PubMed |
description | Radiotherapy-related caries is a complication of radiotherapy for nasopharyngeal carcinoma; however, factors influencing the occurrence, accurate prediction of onset, and protective factors of radiotherapy-related caries remain unclear. This study analyzed risk factors, disease predictors, and protective factors for radiotherapy-related caries in nasopharyngeal carcinoma. This prospective study included 138 nasopharyngeal carcinoma patients receiving radical radiotherapy at our hospital during June 2012–December 2016 and were followed up for dental caries. Patients’ clinical data on radiotherapy were collected, dynamic monitoring was performed to assess changes in oral pH values, and a questionnaire survey was administered to collect patients’ lifestyle habits. Time-dependent cox regression trees, event-free Kaplan–Meier curve, Mann–Whitely U test were used to analysis the results. The median follow-up time was 30 (12–60) months. Radiotherapy-related caries occurred in 28 cases (20.3%). Univariate analyses showed that radiotherapy-related caries was associated with patient’s age, oral saliva pH value, green tea consumption, and radiation dose to sublingual glands, but not with the radiation dose to the parotid and submandibular glands. Multivariate analysis showed that oral saliva pH value [hazard ratio (HR) = 0.390, 95% confidence interval = 0.204–0.746] was an independent prognostic factor for radiotherapy-related caries. Patients with oral saliva pH values ≤ 5.3 in the 9th month after radiotherapy represented a significantly higher risks for radiotherapy-related caries (p < 0.001). Green tea consumption was associated with the occurrence of radiotherapy-related caries, and oral saliva pH values could predict the occurrence of radiotherapy-related caries. Limiting radiation doses to sublingual glands can reduce the occurrence of radiotherapy-related caries. |
format | Online Article Text |
id | pubmed-8192759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81927592021-06-14 Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients Li, Zheng Wu, Qiuji Meng, Xiangyu Yu, Haijun Jiang, Dazhen Chen, Gaili Hu, Xiaoyan Hua, Xinying Wang, Xiaoyong Wang, Dajiang Zhao, Hongli Zhong, Yahua Sci Rep Article Radiotherapy-related caries is a complication of radiotherapy for nasopharyngeal carcinoma; however, factors influencing the occurrence, accurate prediction of onset, and protective factors of radiotherapy-related caries remain unclear. This study analyzed risk factors, disease predictors, and protective factors for radiotherapy-related caries in nasopharyngeal carcinoma. This prospective study included 138 nasopharyngeal carcinoma patients receiving radical radiotherapy at our hospital during June 2012–December 2016 and were followed up for dental caries. Patients’ clinical data on radiotherapy were collected, dynamic monitoring was performed to assess changes in oral pH values, and a questionnaire survey was administered to collect patients’ lifestyle habits. Time-dependent cox regression trees, event-free Kaplan–Meier curve, Mann–Whitely U test were used to analysis the results. The median follow-up time was 30 (12–60) months. Radiotherapy-related caries occurred in 28 cases (20.3%). Univariate analyses showed that radiotherapy-related caries was associated with patient’s age, oral saliva pH value, green tea consumption, and radiation dose to sublingual glands, but not with the radiation dose to the parotid and submandibular glands. Multivariate analysis showed that oral saliva pH value [hazard ratio (HR) = 0.390, 95% confidence interval = 0.204–0.746] was an independent prognostic factor for radiotherapy-related caries. Patients with oral saliva pH values ≤ 5.3 in the 9th month after radiotherapy represented a significantly higher risks for radiotherapy-related caries (p < 0.001). Green tea consumption was associated with the occurrence of radiotherapy-related caries, and oral saliva pH values could predict the occurrence of radiotherapy-related caries. Limiting radiation doses to sublingual glands can reduce the occurrence of radiotherapy-related caries. Nature Publishing Group UK 2021-06-10 /pmc/articles/PMC8192759/ /pubmed/34112869 http://dx.doi.org/10.1038/s41598-021-91600-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Zheng Wu, Qiuji Meng, Xiangyu Yu, Haijun Jiang, Dazhen Chen, Gaili Hu, Xiaoyan Hua, Xinying Wang, Xiaoyong Wang, Dajiang Zhao, Hongli Zhong, Yahua Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients |
title | Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients |
title_full | Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients |
title_fullStr | Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients |
title_full_unstemmed | Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients |
title_short | Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients |
title_sort | oral ph value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192759/ https://www.ncbi.nlm.nih.gov/pubmed/34112869 http://dx.doi.org/10.1038/s41598-021-91600-w |
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