Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

In systemic light chain amyloidosis (AL), pathogenic monoclonal immunoglobulin light chains (LC) form toxic aggregates and amyloid fibrils in target organs. Prompt diagnosis is crucial to avoid permanent organ damage, but delayed diagnosis is common because symptoms usually appear only after strong...

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Detalles Bibliográficos
Autores principales: Garofalo, Maura, Piccoli, Luca, Romeo, Margherita, Barzago, Maria Monica, Ravasio, Sara, Foglierini, Mathilde, Matkovic, Milos, Sgrignani, Jacopo, De Gasparo, Raoul, Prunotto, Marco, Varani, Luca, Diomede, Luisa, Michielin, Olivier, Lanzavecchia, Antonio, Cavalli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192768/
https://www.ncbi.nlm.nih.gov/pubmed/34112780
http://dx.doi.org/10.1038/s41467-021-23880-9

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