Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia

Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the suppression of oncogenic kinase signaling. Here, we test the hypothesis that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT (PI3K/AKT)-signaling pathway may be leveraged to trigger CLL cell death...

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Detalles Bibliográficos
Autores principales: Ecker, Veronika, Stumpf, Martina, Brandmeier, Lisa, Neumayer, Tanja, Pfeuffer, Lisa, Engleitner, Thomas, Ringshausen, Ingo, Nelson, Nina, Jücker, Manfred, Wanninger, Stefan, Zenz, Thorsten, Wendtner, Clemens, Manske, Katrin, Steiger, Katja, Rad, Roland, Müschen, Markus, Ruland, Jürgen, Buchner, Maike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192787/
https://www.ncbi.nlm.nih.gov/pubmed/34112805
http://dx.doi.org/10.1038/s41467-021-23752-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192787/
https://www.ncbi.nlm.nih.gov/pubmed/34112805
http://dx.doi.org/10.1038/s41467-021-23752-2

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