Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells

Recently, we involved the carbohydrate-binding protein Galectin-3 (Gal-3) as a druggable target for KRAS-mutant-addicted lung and pancreatic cancers. Here, using glioblastoma patient-derived stem cells (GSCs), we identify and characterize a subset of Gal-3(high) glioblastoma (GBM) tumors mainly with...

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Detalles Bibliográficos
Autores principales: Seguin, Laetitia, Odouard, Soline, Corlazzoli, Francesca, Haddad, Sarah Al, Moindrot, Laurine, Calvo Tardón, Marta, Yebra, Mayra, Koval, Alexey, Marinari, Eliana, Bes, Viviane, Guérin, Alexandre, Allard, Mathilde, Ilmjärv, Sten, Katanaev, Vladimir L., Walker, Paul R., Krause, Karl-Heinz, Dutoit, Valérie, Sarkaria, Jann N., Dietrich, Pierre-Yves, Cosset, Érika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192788/
https://www.ncbi.nlm.nih.gov/pubmed/34112916
http://dx.doi.org/10.1038/s42003-021-02258-z

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