Heterologous functional expression of ascidian Nav1 channels and close relationship with the evolutionary ancestor of vertebrate Nav channels

Voltage-gated sodium channels (Nav1s) are responsible for the initiation and propagation of action potentials in neurons, muscle, and endocrine cells. Many clinically used drugs such as local anesthetics and antiarrhythmics inhibit Nav1s, and a variety of inherited human disorders are caused by muta...

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Detalles Bibliográficos
Autores principales: Kawai, Takafumi, Hashimoto, Masaki, Eguchi, Natsuki, Nishino, Junko M., Jinno, Yuka, Mori-Kreiner, Risa, Aspåker, Måns, Chiba, Daijiro, Ohtsuka, Yukio, Kawanabe, Akira, Nishino, Atsuo S., Okamura, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192821/
https://www.ncbi.nlm.nih.gov/pubmed/34000300
http://dx.doi.org/10.1016/j.jbc.2021.100783

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